Publications

Authors:

Barbi, Chiara; Temesi, John; Giuriato, Gaia; Laginestra, Fabio Giuseppe; Martignon, Camilla; Moro, Tatiana; Schena, Federico; Venturelli, Massimo; Vernillo, Gianluca

Title:

Skeletal muscle fiber type and TMS-induced muscle relaxation in unfatigued and fatigued knee-extensor muscles

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

ISSN of journal:

0363-6119

N° Volume:

326

Number or Folder:

5

Page numbers:

R438-R447

Keyword:

fatigue; knee extensors; muscle fiber type composition; muscle relaxation rate; transcranial magnetic stimulation

Short description of contents:

The force drop after transcranial magnetic stimulation (TMS) delivered to the motor cortex during voluntary muscle contractions could inform about muscle relaxation properties. Because of the physiological relation between skeletal muscle fiber type distribution and size and muscle relaxation, TMS could be a non-invasive index of muscle relaxation in humans. By combining a non-invasive technique to record muscle relaxation in vivo (TMS) with the gold standard technique for muscle tissue sampling (muscle biopsy), we investigated the relation between TMS-induced muscle relaxation in unfatigued and fatigued states, and muscle fiber type distribution and size. Sixteen participants (7F/9M) volunteered to participate. Maximal knee-extensor voluntary isometric contractions were performed with TMS before and after a 2-min sustained maximal voluntary isometric contraction. Vastus lateralis muscle tissue was obtained separately from the participants' dominant limb. Fiber type I distribution and relative cross-sectional area of fiber type I correlated with TMS-induced muscle relaxation at baseline [r = 0.67, adjusted P = 0.01; r = 0.74, adjusted P = 0.004, respectively] and normalized TMS-induced muscle relaxation as a percentage of baseline [r = 0.50, adjusted P = 0.049; r = 0.56, adjusted P = 0.031, respectively]. The variance in the normalized peak relaxation rate at baseline (59.8%, P < 0.001) and in the fatigue resistance (23.0%, P = 0.035) were explained by the relative cross-sectional area of fiber type I to total fiber area. Fiber type I proportional area influences TMS-induced muscle relaxation, suggesting TMS as an alternative method to non-invasively inform about skeletal muscle relaxation properties.

Web page:

https://doi.org/10.1152/ajpregu.00174.2023

Product ID:

138846

Handle IRIS:

11562/1123608

Last Modified:

May 29, 2024

Bibliographic citation:

Barbi, Chiara; Temesi, John; Giuriato, Gaia; Laginestra, Fabio Giuseppe; Martignon, Camilla; Moro, Tatiana; Schena, Federico; Venturelli, Massimo; Vernillo, Gianluca, Skeletal muscle fiber type and TMS-induced muscle relaxation in unfatigued and fatigued knee-extensor muscles «AMERICAN JOURNAL OF PHYSIOLOGY. REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY» , vol. 326 , n. 5 , 2024 , pp. R438-R447

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