Publications

Authors:

Carton, Flavia; Malatesta, Manuela

Title:

Nanotechnological research for regenerative medicine: the role of hyaluronic acid

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ISSN of journal:

1422-0067

N° Volume:

25

Number or Folder:

7

Page numbers:

1-16

Keyword:

hyaluronic acid; hyaluronan; tissue engineering; hydrogel; nanoparticle; cartilage regeneration; bone regeneration; wound healing; angiogenesis; neural regeneration

Short description of contents:

Hyaluronic acid (HA) is a linear, anionic, non-sulfated glycosaminoglycan occurring in almost all body tissues and fluids of vertebrates including humans. It is a main component of the extracellular matrix and, thanks to its high water-holding capacity, plays a major role in tissue hydration and osmotic pressure maintenance, but it is also involved in cell proliferation, differentiation and migration, inflammation, immunomodulation, and angiogenesis. Based on multiple physiological effects on tissue repair and reconstruction processes, HA has found extensive application in regenerative medicine. In recent years, nanotechnological research has been applied to HA in order to improve its regenerative potential, developing nanomedical formulations containing HA as the main component of multifunctional hydrogels systems, or as core component or coating/functionalizing element of nanoconstructs. This review offers an overview of the various uses of HA in regenerative medicine aimed at designing innovative nanostructured devices to be applied in various fields such as orthopedics, dermatology, and neurology.

Web page:

https://doi.org/10.3390/ijms25073975

Product ID:

139017

Handle IRIS:

11562/1124731

Last Modified:

June 15, 2024

Bibliographic citation:

Carton, Flavia; Malatesta, Manuela, Nanotechnological research for regenerative medicine: the role of hyaluronic acid «INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES» , vol. 25 , n. 7 , 2024 , pp. 1-16

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