Pubblicazioni

Autori:

Locatelli, Francesca; Martinelli, Luigi; Marchetti, Pierpaolo; Caliskan, Gulser; Badaloni, Chiara; Caranci, Nicola; de Hoogh, Kees; Gatti, Luciana; Rossi, Paolo Giorgi; Guarda, Linda; Ottone, Marta; Panunzi, Silvia; Stafoggia, Massimo; Silocchi, Caterina; Ricci, Paolo; Marcon, Alessandro

Titolo:

Residential exposure to air pollution and incidence of leukaemia in the industrial area of Viadana, Northern Italy

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

ENVIRONMENTAL RESEARCH

ISSN Rivista:

0013-9351

N° Volume:

254

Intervallo pagine:

1-10

Parole chiave:

Cancer; case-control study; epidemiology; formaldehyde; general population; leukaemia; outdoor air pollution

Breve descrizione dei contenuti:

Background: Exposure to air pollution has been proposed as one of the potential risk factors for leukaemia. Work-related formaldehyde exposure is suspected to cause leukaemia. Methods: We conducted a nested register-based case-control study on leukaemia incidence in the Viadana district, an industrial area for particleboard production in Northern Italy. We recruited 115 cases and 496 controls, frequency-matched by age, between 1999-2014. We assigned estimated exposures to particulate matter (PM10, PM2.5), nitrogen dioxide (NO2), and formaldehyde at residential addresses, averaged over the susceptibility window 3rd to 10th year prior to the index date. We considered potential confounding by sex, age, nationality, socio-economic status, occupational exposures to benzene and formaldehyde, and prior cancer diagnoses. Results: There was no association of exposures to PM10, PM2.5, and NO2 with leukaemia incidence. However, an indication of increased risk emerged for formaldehyde, despite wide statistical uncertainty (OR 1.46, 95%CI 0.65-3.25 per IQR-difference of 1.2 μg/m3). Estimated associations for formaldehyde were higher for acute (OR 2.07, 95%CI 0.70-6.12) and myeloid subtypes (OR 1.79, 95%CI 0.64-5.01), and in the 4-km buffer around the industrial facilities (OR 2.78, 95%CI 0.48-16.13), although they remained uncertain. Conclusions: This was the first study investigating the link between ambient formaldehyde exposure and leukaemia incidence in the general population. The evidence presented suggests an association, although it remains inconclusive, and a potential significance of emissions related to industrial activities in the district. Further research is warranted in larger populations incorporating data on other potential risk factors.

Id prodotto:

139631

Handle IRIS:

11562/1126388

ultima modifica:

27 ottobre 2024

Citazione bibliografica:

Locatelli, Francesca; Martinelli, Luigi; Marchetti, Pierpaolo; Caliskan, Gulser; Badaloni, Chiara; Caranci, Nicola; de Hoogh, Kees; Gatti, Luciana; Rossi, Paolo Giorgi; Guarda, Linda; Ottone, Marta; Panunzi, Silvia; Stafoggia, Massimo; Silocchi, Caterina; Ricci, Paolo; Marcon, Alessandro, Residential exposure to air pollution and incidence of leukaemia in the industrial area of Viadana, Northern Italy «ENVIRONMENTAL RESEARCH» , vol. 254 , 2024 , pp. 1-10

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo