Pubblicazioni

Autori:

Pancheri, Serena; Pertile, Riccardo; Armelao, Franco; Rizzello, Roberto Vito; Piffer, Silvano; Zorzi, Manuel; Guzzinati, Stefano; Ferro, Antonio; Mantovani, William; de Pretis, Giovanni

Titolo:

A comprehensive assessment of the impact of a colorectal cancer screening program in a northern Italian area

Anno:

2022

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

Digestive Liver Disease

ISSN Rivista:

1590-8658

N° Volume:

54

Numero o Fascicolo:

3

Editore:

EGI srl

Intervallo pagine:

400-406

Parole chiave:

Cancer epidemiology; Cancer prevention; Colorectal cancer screening; Hemoccult

Breve descrizione dei contenuti:

Background: The impact of a faecal immunochemical test-based colorectal cancer (CRC) screening program in terms of patient prognosis could be affected by lead-time bias, which artificially increases the survival of screen-detected patients due to the early diagnosis.Aims: To provide a description of the impact of the CRC screening program in the Trentino Region (Italy), including the Cure Fraction (CF), a prognostic indicator not affected by lead-time bias.Methods: The program started in 2008, inviting the resident population aged 50-69 years. In this retrospective cohort study, 1,697 CRC diagnosed between 2003 and 2014 in patients aged 50-69 years were classified as pre-screening (PS), screen-detected (SD), interval cancers (IC) and not-screen-detected (NSD). We compared groups by stage at diagnosis and CF. Trends in CRC mortality were reported. Results: The proportion of stage I among SD cases was 51%, higher than PS (19%; OR 4.66, 95%CI 3.50- 6.20), NSD (20.6%; OR 3.96, 95%CI 2.95-5.32) and IC (33.3%; OR 2.11, 95%CI 1.10-4.04). The CF of PS, NSD and SD cases was respectively 57% (95%CI 54-60%), 60% (95%CI 58-63%) and 93% (95%CI 89-96%). CRC mortality dropped from 40.7 to 25.6 \ 10 0,0 0 0.Conclusion: The program significantly improved the prognosis of patients, decreasing CRC mortality and incidence of advanced CRCs. (c) 2021 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

Id prodotto:

140193

Handle IRIS:

11562/1128891

ultima modifica:

21 giugno 2024

Citazione bibliografica:

Pancheri, Serena; Pertile, Riccardo; Armelao, Franco; Rizzello, Roberto Vito; Piffer, Silvano; Zorzi, Manuel; Guzzinati, Stefano; Ferro, Antonio; Mantovani, William; de Pretis, Giovanni, A comprehensive assessment of the impact of a colorectal cancer screening program in a northern Italian area «Digestive Liver Disease» , vol. 54 , n. 3 , 2022 , pp. 400-406

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