Publications

Authors:

Turano, Ermanna; Virla, Federica; Scambi, Ilaria; Dabrowska, Sylwia; Bankole, Oluwamolakun; Mariotti, Raffaella

Title:

Adipose mesenchymal stem cells-derived extracellular vesicles exert their preferential action in damaged central sites of SOD1 mice rather than peripherally

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

EUROPEAN JOURNAL OF HISTOCHEMISTRY

ISSN of journal:

2038-8306

N° Volume:

68

Number or Folder:

3

Page numbers:

1-9

Keyword:

amyotrophic lateral sclerosis; extracellular vesicles; stem cells; exosomes, SOD1(G93A); neuroprotection; motor neurons

Short description of contents:

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder involving motor neuron (MN) loss in the motor cortex, brainstem and spinal cord leading to progressive paralysis and death. Due to the pathogenetic complexity, there are no effective therapies available. In this context the use of mesenchymal stem cells and their vesicular counterpart is an emerging therapeutic strategy to counteract neurodegeneration. The extracellular vesicles derived from adipose stem cells (ASC-EVs) recapitulate and ameliorate the neuroprotective effect of stem cells and, thanks to their small dimensions, makes their use suitable to develop novel therapeutic approaches for neurodegenerative diseases as ALS. Here we investigate a therapeutic regimen of ASC-EVs injection in SOD1(G93A) mice, the most widely used murine model of ALS. Repeated intranasal administrations of high doses of ASC-EVs were able to ameliorate motor performance of injected SOD1(G93A) mice at the early stage of the disease and produce a significant improvement at the end-stage in the lumbar MNs rescue. Moreover, ASC-EVs preserve the structure of neuromuscular junction without counteracting the muscle atrophy. The results indicate that the intranasal ASC-EVs administration acts in central nervous system sites rather than at peripheral level in SOD1(G93A) mice. These considerations allow us to identify future applications of ASC-EVs that involve different targets simultaneously to maximize the clinical and neuropathological outcomes in ALS in vivo models.

Note:

Ermanna Turano and Federica Virla contributed equally.

Web page:

https://doi.org/10.4081/ejh.2024.4040

Product ID:

140411

Handle IRIS:

11562/1130529

Last Modified:

August 9, 2024

Bibliographic citation:

Turano, Ermanna; Virla, Federica; Scambi, Ilaria; Dabrowska, Sylwia; Bankole, Oluwamolakun; Mariotti, Raffaella, Adipose mesenchymal stem cells-derived extracellular vesicles exert their preferential action in damaged central sites of SOD1 mice rather than peripherally «EUROPEAN JOURNAL OF HISTOCHEMISTRY» , vol. 68 , n. 3 , 2024 , pp. 1-9

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