Publications

Authors:

Samadzadeh, Sara; Adnan, Rafl; Berglova, Paulina; Barzegar, Mahdi; Debrabant, Birgit; Roikjaer, Stine Gundtoft; Levy, Michael; Petzold, Axel; Palace, Jacqueline; Flanagan, Eoin P; Mariotto, Sara; Skou, Soeren T; Froelich, Anne; Lotan, Itay; Messina, Silvia; Geraldes, Ruth; Asseyer, Susanna; Stiebel-Kalish, Hadas; Oertel, Frederike Cosima; Shaygannejad, Vahid; Sahraian, Mohammad Ali; Kim, Ho Jin; Bennett, Jeffrey L; Böttcher, Chotima; Zimmermann, Hanna G; Weinshenker, Brian G; Paul, Friedemann; Asgari, Nasrin

Title:

Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT)

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

FRONTIERS IN IMMUNOLOGY

ISSN of journal:

1664-3224

N° Volume:

15

Number or Folder:

1380025

Page numbers:

1-14

Keyword:

antibody-mediated diseases of the central nervous system; comorbidity; multiple sclerosis; myelin oligodendrocyte glycoprotein antibody-associated disease; neuromyelitis optica spectrum disorder

Short description of contents:

Comorbidities in patients with multiple sclerosis (MS) and antibody-mediated diseases of the central nervous system (CNS) including neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease (MOGAD) are common and may influence the course of their neurological disease. Comorbidity may contribute to neuronal injury and therefore limit recovery from attacks, accelerate disease progression, and increase disability. This study aims to explore the impact of comorbidity, particularly vascular comorbidity, and related risk factors on clinical and paraclinical parameters of MS, NMOSD and MOGAD. We propose COMMIT, a prospective multicenter study with longitudinal follow-up of patients with MS, NMOSD, and MOGAD, with or without comorbidities, as well as healthy subjects as controls. Subjects will be stratified by age, sex and ethnicity. In consecutive samples we will analyze levels of inflammation and neurodegeneration markers in both fluid and cellular compartments of the peripheral blood and cerebrospinal fluid (CSF) using multiple state-of-the-art technologies, including untargeted proteomics and targeted ultrasensitive ELISA assays and quantitative reverse transcription polymerase chain reaction (RT-qPCR) as well as high-dimensional single-cell technologies i.e., mass cytometry and single-cell RNA sequencing. Algorithm-based data analyses will be used to unravel the relationship between these markers, optical coherence tomography (OCT) and magnetic resonance imaging (MRI), and clinical outcomes including frequency and severity of relapses, long-term disability, and quality of life. The goal is to evaluate the impact of comorbidities on MS, NMOSD, and MOGAD which may lead to development of treatment approaches to improve outcomes of inflammatory demyelinating diseases of the CNS.

Web page:

https://doi.org/10.3389/fimmu.2024.1380025

Product ID:

141266

Handle IRIS:

11562/1138926

Last Modified:

October 2, 2024

Bibliographic citation:

Samadzadeh, Sara; Adnan, Rafl; Berglova, Paulina; Barzegar, Mahdi; Debrabant, Birgit; Roikjaer, Stine Gundtoft; Levy, Michael; Petzold, Axel; Palace, Jacqueline; Flanagan, Eoin P; Mariotto, Sara; Skou, Soeren T; Froelich, Anne; Lotan, Itay; Messina, Silvia; Geraldes, Ruth; Asseyer, Susanna; Stiebel-Kalish, Hadas; Oertel, Frederike Cosima; Shaygannejad, Vahid; Sahraian, Mohammad Ali; Kim, Ho Jin; Bennett, Jeffrey L; Böttcher, Chotima; Zimmermann, Hanna G; Weinshenker, Brian G; Paul, Friedemann; Asgari, Nasrin, Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT) «FRONTIERS IN IMMUNOLOGY» , vol. 15 , n. 1380025 , 2024 , pp. 1-14

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