Publications

Authors:

Arienti, Federica; Casazza, Giovanni; Franco, Giulia; Lazzeri, Giulia; Monfrini, Edoardo; Di Maio, Alessandro; Erro, Roberto; Barone, Paolo; Tamma, Filippo; Caputo, Elena; Volontè, Maria Antonietta; Cacciaguerra, Laura; Pilotto, Andrea; Padovani, Alessandro; Comi, Cristoforo; Magistrelli, Luca; Valzania, Franco; Cavallieri, Francesco; Avanzino, Laura; Marchese, Roberta; Sensi, Mariachiara; Carroli, Giorgia; Eleopra, Roberto; Cilia, Roberto; Spagnolo, Francesca; Tessitore, Alessandro; De Micco, Rosa; Ceravolo, Roberto; Palermo, Giovanni; Malaguti, Maria Chiara; Lopiano, Leonardo; Tocco, Pierluigi; Sorbera, Chiara; Tinazzi, Michele; Ciammola, Andrea; Ottaviani, Donatella; Valente, Enza Maria; Albanese, Alberto; Blandini, Fabio; Canesi, Margherita; Antonini, Angelo; Carecchio, Miryam; Fetoni, Vincenza; Colosimo, Carlo; Volpe, Daniele; Tambasco, Nicola; Cossu, Giovanni; Zappia, Mario; Di Fonzo, Alessio

Title:

Family History in Parkinson's Disease: A National Cross-Sectional Study

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

MOVEMENT DISORDERS CLINICAL PRACTICE

ISSN of journal:

2330-1619

N° Volume:

11

Number or Folder:

11

Page numbers:

1434-1440

Keyword:

bipolar disorder; cognitive impairment; depression; familial and sporadic Parkinson's disease; family history; hyposmia

Short description of contents:

Background: Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect. Objectives: We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD). Methods: A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected. Results: Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group. Conclusions: fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.

Web page:

https://doi.org/10.1002/mdc3.14206

Product ID:

141911

Handle IRIS:

11562/1143726

Last Modified:

November 28, 2024

Bibliographic citation:

Arienti, Federica; Casazza, Giovanni; Franco, Giulia; Lazzeri, Giulia; Monfrini, Edoardo; Di Maio, Alessandro; Erro, Roberto; Barone, Paolo; Tamma, Filippo; Caputo, Elena; Volontè, Maria Antonietta; Cacciaguerra, Laura; Pilotto, Andrea; Padovani, Alessandro; Comi, Cristoforo; Magistrelli, Luca; Valzania, Franco; Cavallieri, Francesco; Avanzino, Laura; Marchese, Roberta; Sensi, Mariachiara; Carroli, Giorgia; Eleopra, Roberto; Cilia, Roberto; Spagnolo, Francesca; Tessitore, Alessandro; De Micco, Rosa; Ceravolo, Roberto; Palermo, Giovanni; Malaguti, Maria Chiara; Lopiano, Leonardo; Tocco, Pierluigi; Sorbera, Chiara; Tinazzi, Michele; Ciammola, Andrea; Ottaviani, Donatella; Valente, Enza Maria; Albanese, Alberto; Blandini, Fabio; Canesi, Margherita; Antonini, Angelo; Carecchio, Miryam; Fetoni, Vincenza; Colosimo, Carlo; Volpe, Daniele; Tambasco, Nicola; Cossu, Giovanni; Zappia, Mario; Di Fonzo, Alessio, Family History in Parkinson's Disease: A National Cross-Sectional Study «MOVEMENT DISORDERS CLINICAL PRACTICE» , vol. 11 , n. 11 , 2024 , pp. 1434-1440

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