Pubblicazioni

Autori:

Ocón, Borja; Xiang, Menglan; Bi, Yuhan; Tan, Serena; Brulois, Kevin; Ayesha, Aiman; Kunte, Manali; Zhou, Catherine; Lajevic, Melissa; Lazarus, Nicole; Mengoni, Francesca; Sharma, Tanya; Montgomery, Stephen; Hooper, Jody E; Huang, Mian; Handel, Tracy; Dawson, John R D; Kufareva, Irina; Zabel, Brian A; Pan, Junliang; Butcher, Eugene C

Titolo:

A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Nature

ISSN Rivista:

0028-0836

N° Volume:

635

Numero o Fascicolo:

8039

Intervallo pagine:

736-745

Parole chiave:

CD8-positive T cells; Chemokines; Data mining; Mucosal immunology; Protein sequence analyses

Breve descrizione dei contenuti:

Tissue-selective chemoattractants direct lymphocytes to epithelial surfaces to establish local immune environments, regulate immune responses to food antigens and commensal organisms, and protect from pathogens. Homeostatic chemoattractants for small intestines, colon, and skin are known1 2, but chemotropic mechanisms selective for respiratory tract and other non-intestinal mucosal tissues (NIMT) remain poorly understood. Here we leveraged diverse omics datasets to identify GPR25 as a lymphocyte receptor for CXCL17, a chemoattractant cytokine whose expression by epithelial cells of airways, upper gastrointestinal and squamous mucosae unifies the NIMT and distinguishes them from intestinal mucosae. Single-cell transcriptomic analyses show that GPR25 is induced on innate lymphocytes prior to emigration to the periphery, and is imprinted in secondary lymphoid tissues on activated B and T cells responding to immune challenge. GPR25 characterizes B and T tissue resident memory and regulatory T lymphocytes in NIMT and lungs in humans and mediates lymphocyte homing to barrier epithelia of the airways, oral cavity, stomach, biliary and genitourinary tracts in mouse models. GPR25 is also expressed by T cells in cerebrospinal fluid and CXCL17 by neurons, suggesting a role in CNS immune regulation. We reveal widespread imprinting of GPR25 on regulatory T cells, suggesting a mechanistic link to population genetic evidence that GPR25 is protective in autoimmunity3,4. Our results define a GPR25-CXCL17 chemoaffinity axis with the potential to integrate immunity and tolerance at non-intestinal mucosae and the CNS.

Pagina Web:

https://doi.org/10.1038/s41586-024-08043-2

Id prodotto:

141942

Handle IRIS:

11562/1143950

ultima modifica:

28 novembre 2024

Citazione bibliografica:

Ocón, Borja; Xiang, Menglan; Bi, Yuhan; Tan, Serena; Brulois, Kevin; Ayesha, Aiman; Kunte, Manali; Zhou, Catherine; Lajevic, Melissa; Lazarus, Nicole; Mengoni, Francesca; Sharma, Tanya; Montgomery, Stephen; Hooper, Jody E; Huang, Mian; Handel, Tracy; Dawson, John R D; Kufareva, Irina; Zabel, Brian A; Pan, Junliang; Butcher, Eugene C, A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS «Nature» , vol. 635 , n. 8039 , 2024 , pp. 736-745

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