Pubblicazioni

Autori:

Bonetto, Valentina; Pagano, Corinna Anais; Sabbatini, Maurizio; Magnelli, Valeria; Donadelli, Massimo; Marengo, Emilio; Masini, Maria Angela

Titolo:

Microgravity as a Tool to Investigate Cancer Induction in Pleura Mesothelial Cells

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

CURRENT ISSUES IN MOLECULAR BIOLOGY

ISSN Rivista:

1467-3045

N° Volume:

46

Numero o Fascicolo:

10

Intervallo pagine:

10896-10912

Parole chiave:

BR95 cells; Fibulin-3; MeT-5A cells; NANOG; connexin-43; focal contacts; mesothelioma

Breve descrizione dei contenuti:

The present work shows that the exposure of mesothelial cells to simulated microgravity changes their cytoskeleton and adhesion proteins, leading to a cell switch from normal towards tumoral cells. Immunohistochemical and molecular data were obtained from both MeT-5A exposed to simulated microgravity and BR95 mesothelioma cell lines. Simulated microgravity was found to affect the expression of actin, vinculin, and connexin-43, altering their quantitative and spatial distribution pattern inside the cell. The analysis of the tumoral markers p27, CD44, Fibulin-3, and NANOG and the expression of genes related to cancer transformation such as NANOG, CDH-1, and Zeb-1 showed that the simulated microgravity environment led to expression patterns in MeT-5A cells similar to those observed in BR95 cells. The alteration in both quantitative expression and structural organization of the cytoskeleton and adhesion/communication proteins can thus be considered a pivotal mechanism involved in the cellular shift towards tumoral progression.

Pagina Web:

https://doi.org/10.3390/cimb46100647

Id prodotto:

142174

Handle IRIS:

11562/1144327

ultima modifica:

22 dicembre 2024

Citazione bibliografica:

Bonetto, Valentina; Pagano, Corinna Anais; Sabbatini, Maurizio; Magnelli, Valeria; Donadelli, Massimo; Marengo, Emilio; Masini, Maria Angela, Microgravity as a Tool to Investigate Cancer Induction in Pleura Mesothelial Cells «CURRENT ISSUES IN MOLECULAR BIOLOGY» , vol. 46 , n. 10 , 2024 , pp. 10896-10912

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