Publications

Authors:

Mantovani, Elisa; Martini, Alice; Dinoto, Alessandro; Zucchella, Chiara; Ferrari, Sergio; Mariotto, Sara; Tinazzi, Michele; Tamburin, Stefano

Title:

Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

NPJ PARKINSON'S DISEASE

ISSN of journal:

2373-8057

N° Volume:

10

Number or Folder:

211

Page numbers:

1-17

Keyword:

Diagnostic markers; Parkinson's disease; Prognostic markers

Short description of contents:

Cognitive impairment (CI) is common in α-synucleinopathies, i.e., Parkinson's disease, Lewy bodies dementia, and multiple system atrophy. We summarize data from systematic reviews/meta-analyses on neuroimaging, neurophysiology, biofluid and genetic diagnostic/prognostic biomarkers of CI in α-synucleinopathies. Diagnostic biomarkers include atrophy/functional neuroimaging brain changes, abnormal cortical amyloid and tau deposition, and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers, cortical rhythm slowing, reduced cortical cholinergic and glutamatergic and increased cortical GABAergic activity, delayed P300 latency, increased plasma homocysteine and cystatin C and decreased vitamin B12 and folate, increased CSF/serum albumin quotient, and serum neurofilament light chain. Prognostic biomarkers include brain regional atrophy, cortical rhythm slowing, CSF amyloid biomarkers, Val66Met polymorphism, and apolipoprotein-E ε2 and ε4 alleles. Some AD/amyloid/tau biomarkers may diagnose/predict CI in α-synucleinopathies, but single, validated diagnostic/prognostic biomarkers lack. Future studies should include large consortia, biobanks, multi-omics approach, artificial intelligence, and machine learning to better reflect the complexity of CI in α-synucleinopathies.

Web page:

https://doi.org/10.1038/s41531-024-00823-x

Product ID:

142358

Handle IRIS:

11562/1144606

Last Modified:

December 11, 2024

Bibliographic citation:

Mantovani, Elisa; Martini, Alice; Dinoto, Alessandro; Zucchella, Chiara; Ferrari, Sergio; Mariotto, Sara; Tinazzi, Michele; Tamburin, Stefano, Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses «NPJ PARKINSON'S DISEASE» , vol. 10 , n. 211 , 2024 , pp. 1-17

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