Pubblicazioni

Autori:

Mantovani, Elisa; Martini, Alice; Dinoto, Alessandro; Zucchella, Chiara; Ferrari, Sergio; Mariotto, Sara; Tinazzi, Michele; Tamburin, Stefano

Titolo:

Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses

Anno:

2024

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

NPJ PARKINSON'S DISEASE

ISSN Rivista:

2373-8057

N° Volume:

10

Numero o Fascicolo:

211

Intervallo pagine:

1-17

Parole chiave:

Diagnostic markers; Parkinson's disease; Prognostic markers

Breve descrizione dei contenuti:

Cognitive impairment (CI) is common in α-synucleinopathies, i.e., Parkinson's disease, Lewy bodies dementia, and multiple system atrophy. We summarize data from systematic reviews/meta-analyses on neuroimaging, neurophysiology, biofluid and genetic diagnostic/prognostic biomarkers of CI in α-synucleinopathies. Diagnostic biomarkers include atrophy/functional neuroimaging brain changes, abnormal cortical amyloid and tau deposition, and cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers, cortical rhythm slowing, reduced cortical cholinergic and glutamatergic and increased cortical GABAergic activity, delayed P300 latency, increased plasma homocysteine and cystatin C and decreased vitamin B12 and folate, increased CSF/serum albumin quotient, and serum neurofilament light chain. Prognostic biomarkers include brain regional atrophy, cortical rhythm slowing, CSF amyloid biomarkers, Val66Met polymorphism, and apolipoprotein-E ε2 and ε4 alleles. Some AD/amyloid/tau biomarkers may diagnose/predict CI in α-synucleinopathies, but single, validated diagnostic/prognostic biomarkers lack. Future studies should include large consortia, biobanks, multi-omics approach, artificial intelligence, and machine learning to better reflect the complexity of CI in α-synucleinopathies.

Pagina Web:

https://doi.org/10.1038/s41531-024-00823-x

Id prodotto:

142358

Handle IRIS:

11562/1144606

ultima modifica:

11 dicembre 2024

Citazione bibliografica:

Mantovani, Elisa; Martini, Alice; Dinoto, Alessandro; Zucchella, Chiara; Ferrari, Sergio; Mariotto, Sara; Tinazzi, Michele; Tamburin, Stefano, Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses «NPJ PARKINSON'S DISEASE» , vol. 10 , n. 211 , 2024 , pp. 1-17

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo