Publications

Authors:

Roldan, L; Sánchez-Gutiérrez, T; Fernández-Arias, I; Rodríguez-Toscano, E; López, G; Merchán-Naranjo, J; Calvo, A; Rapado-Castro, M; Parellada, M; Moreno, C; Ferraro, L; La Barbera, D; La Cascia, C; Tripoli, G; Di Forti, M; Murray, R M; Quattrone, D; Morgan, C; Gayer-Anderson, C; Jones, P B; Jongsma, H E; Kirkbride, J B; van Os, J; García-Portilla, P; Al-Halabí, S; Bobes, J; de Haan, L; Bernardo, M; Santos, J L; Sanjuán, J; Arrojo, M; Szoke, A; Rutten, B P; Stilo, S A; Tarricone, I; Lasalvia, A; Tosato, S; Llorca, P-M; Menezes, P Rossi; Selten, J-P; Tortelli, A; Velthorst, E; Del-Ben, C M; Arango, C; Díaz-Caneja, C M

Title:

Cannabis use and cognitive biases in people with first-episode psychosis and their siblings

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Psychological Medicine

ISSN of journal:

0033-2917

N° Volume:

54

Number or Folder:

15

Page numbers:

4095-4105

Keyword:

aberrance salience; cannabis; cognition; facial recognition; jumping to conclusions

Short description of contents:

Background: Cannabis use and familial vulnerability to psychosis have been associated with social cognition deficits. This study examined the potential relationship between cannabis use and cognitive biases underlying social cognition and functioning in patients with first episode psychosis (FEP), their siblings, and controls. Methods: We analyzed a sample of 543 participants with FEP, 203 siblings, and 1168 controls from the EU-GEI study using a correlational design. We used logistic regression analyses to examine the influence of clinical group, lifetime cannabis use frequency, and potency of cannabis use on cognitive biases, accounting for demographic and cognitive variables. Results: FEP patients showed increased odds of facial recognition processing (FRP) deficits (OR = 1.642, CI 1.123-2.402) relative to controls but not of speech illusions (SI) or jumping to conclusions (JTC) bias, with no statistically significant differences relative to siblings. Daily and occasional lifetime cannabis use were associated with decreased odds of SI (OR = 0.605, CI 0.368-0.997 and OR = 0.646, CI 0.457-0.913 respectively) and JTC bias (OR = 0.625, CI 0.422-0.925 and OR = 0.602, CI 0.460-0.787 respectively) compared with lifetime abstinence, but not with FRP deficits, in the whole sample. Within the cannabis user group, low-potency cannabis use was associated with increased odds of SI (OR = 1.829, CI 1.297-2.578, FRP deficits (OR = 1.393, CI 1.031-1.882, and JTC (OR = 1.661, CI 1.271-2.171) relative to high-potency cannabis use, with comparable effects in the three clinical groups. Conclusions: Our findings suggest increased odds of cognitive biases in FEP patients who have never used cannabis and in low-potency users. Future studies should elucidate this association and its potential implications.

Web page:

https://doi.org/10.1017/S0033291724001715

Product ID:

142741

Handle IRIS:

11562/1145594

Last Modified:

January 11, 2025

Bibliographic citation:

Roldan, L; Sánchez-Gutiérrez, T; Fernández-Arias, I; Rodríguez-Toscano, E; López, G; Merchán-Naranjo, J; Calvo, A; Rapado-Castro, M; Parellada, M; Moreno, C; Ferraro, L; La Barbera, D; La Cascia, C; Tripoli, G; Di Forti, M; Murray, R M; Quattrone, D; Morgan, C; Gayer-Anderson, C; Jones, P B; Jongsma, H E; Kirkbride, J B; van Os, J; García-Portilla, P; Al-Halabí, S; Bobes, J; de Haan, L; Bernardo, M; Santos, J L; Sanjuán, J; Arrojo, M; Szoke, A; Rutten, B P; Stilo, S A; Tarricone, I; Lasalvia, A; Tosato, S; Llorca, P-M; Menezes, P Rossi; Selten, J-P; Tortelli, A; Velthorst, E; Del-Ben, C M; Arango, C; Díaz-Caneja, C M, Cannabis use and cognitive biases in people with first-episode psychosis and their siblings «Psychological Medicine» , vol. 54 , n. 15 , 2024 , pp. 4095-4105

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