Publications

Authors:

Liberati, Cecilia; Barbieri, Elisa; Cavagnero, Francesca; Petris, Maria Grazia; Brigadoi, Giulia; Reggiani, Giulia; De Pieri, Marica; Pierobon, Marta; Marzollo, Antonio; Gabelli, Maria; Trivellato, Sabrina; Rigotti, Erika; Opri, Francesca; Mengato, Daniele; Venturini, Francesca; De Canale, Ettore; Del Vecchio, Claudia; Giaquinto, Carlo; Carrara, Elena; Tacconelli, Evelina; Biffi, Alessandra; Donà, Daniele

Title:

Impact of a two step antimicrobial stewardship program in a paediatric haematology and oncology unit

Year:

2024

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

No

Name of journal:

SCIENTIFIC REPORTS

ISSN of journal:

2045-2322

N° Volume:

14

Number or Folder:

1

Page numbers:

1-11

Keyword:

Antibiotics.; Antimicrobial stewardship; Pediatric Oncology Haematology; Stem cell transplantation

Short description of contents:

Objective: To describe the implementation of a multi-step antimicrobial stewardship program in a haemato-oncology and stem cell transplantation program unit. Methods: Pre-post quasi-experimental study with two interrupted time-series analyses, conducted between 01/01/2019 and 31/12/2022 in the Paediatric Haemato-Oncology Unit of the Padua Paediatric Hospital. The interventions were: (1) 02/2020: dissemination of febrile neutropenia clinical pathways, (2) April 2021: provision of the clinical pathways via a customized App (Firstline.org) and implementation of a twice-a-week prospective audit and feedback. The main outcome was antibiotic consumption measured by days of administered therapy (DOTs)/1000 patients' days for all antibiotics and most used molecules. Results: The first intervention (clinical pathways) resulted in a decrease in the overall antibiotic use by the haemato-oncology unit, with an abrupt reduction of 3-gen cephalosporins in favor of piperacillin-tazobactam, as indicated by the clinical pathways. Meropenem and glycopeptide use did not vary. The second intervention (antimicrobial stewardship) further decreased total antibiotic consumption, and a significant decline in meropenem, amikacin, and glycopeptides was achieved. Conclusions: Multi-step stewardship based on guidelines dissemination, multidisciplinary team intervention and collaboration ("handshake" stewardship) was highly effective in optimizing guidelines adherence and reducing overprescriptions in a fragile patient cohort.

Note:

Cecilia Liberati, Elisa Barbieri share first authorship. Alessandra Biffi and Daniele Donà share last authorship.

Product ID:

142845

Handle IRIS:

11562/1145887

Last Modified:

January 30, 2025

Bibliographic citation:

Liberati, Cecilia; Barbieri, Elisa; Cavagnero, Francesca; Petris, Maria Grazia; Brigadoi, Giulia; Reggiani, Giulia; De Pieri, Marica; Pierobon, Marta; Marzollo, Antonio; Gabelli, Maria; Trivellato, Sabrina; Rigotti, Erika; Opri, Francesca; Mengato, Daniele; Venturini, Francesca; De Canale, Ettore; Del Vecchio, Claudia; Giaquinto, Carlo; Carrara, Elena; Tacconelli, Evelina; Biffi, Alessandra; Donà, Daniele, Impact of a two step antimicrobial stewardship program in a paediatric haematology and oncology unit «SCIENTIFIC REPORTS» , vol. 14 , n. 1 , 2024 , pp. 1-11

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