Publications

Authors:

Quaranta, Davide; L'Abbate, Federica; Pelosi, Annalisa; Arighi, Andrea; Asoni, Gesuina; Bagattini, Chiara; Bessi, Valentina; Bonanni, Laura; Bortoletto, Marta; Bruni, Amalia Cecilia; Cagnin, Annachiara; Cappa, Stefano F; Giubilei, Franco; Guarino, Maria; Iavarone, Alessandro; Isella, Valeria; Luca, Antonina; Monastero, Roberto; Pellegrini, Francesca Ferrari; Perini, Marta; Piccoli, Tommaso; Rainero, Innocenzo; Tedeschi, Gioacchino; Marra, Camillo; Caffarra, Paolo

Title:

Itel MMSE: a short phone screening test for cognitive decline. Italian Validation study by the SINdem Neuropsychology Working Group

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

NEUROLOGICAL SCIENCES

ISSN of journal:

1590-1874

N° Volume:

46

Number or Folder:

4

Page numbers:

1617-1627

Keyword:

Alzheimer's disease; Cognitive screening; Dementia; ItelMMSE; MCI; Neurospychology

Short description of contents:

Introduction: The Italian telephone-based Mini-Mental State Examination (Itel-MMSE) is considered a very easy tool for screening individuals with dementia, gained importance during COVID-19, but lacks validation and faces a ceiling effect. Aim: In the present study, we conducted a study standardizing and validating it, establishing cut-off values for two versions. Methods: Across 24 Italian sites, 707 healthy individuals (50-89 years, men: 268, women: 439) with diverse educational levels (3-24 years) were recruited. Subjects met criteria for normal conditions investigated through a semi-structured interview covering neurological, psychiatric, general medical, and psychopharmacological history. Two test versions were created to assess test-retest reliability at 45-day intervals. We also enrolled 187 subjects with Mild Cognitive Impairment (MCI) and 181 with Alzheimer's Disease (AD) for validation. The raw scores obtained on both versions of Itel-MMSE were set as dependent variables in linear regression models that included age, education, and gender as independent variables. RESULTS : Mean raw Itel-MMSE1 score was 20.82 (range: 13-22). Multiple linear regression demonstrated significant effects of sociodemographic variables for age and education, establishing a new cut-off ≥ 18.49. Mean raw Itel-MMSE2 score was 20.97 (range: 10-22), with a new cut-off ≥ 18.45. Validation showed high informative values, with areas under the curve (AUCs) for MCI and AD conditions and both versions (Itel-MMSE1: MCI AUC = 0.801, AD AUC = 0.907; Itel-MMSE2: MCI AUC = 0.827, AD AUC = 0.977). Conclusion: The Itel-MMSE proves valuable as a screening method for detecting and monitoring dementia in remote phone screenings, with different cut-offs aiding MCI patient identification in clinical settings.

Note:

First published online: 04 December 2024

Web page:

https://doi.org/10.1007/s10072-024-07863-4

Product ID:

142939

Handle IRIS:

11562/1146448

Last Modified:

March 21, 2025

Bibliographic citation:

Quaranta, Davide; L'Abbate, Federica; Pelosi, Annalisa; Arighi, Andrea; Asoni, Gesuina; Bagattini, Chiara; Bessi, Valentina; Bonanni, Laura; Bortoletto, Marta; Bruni, Amalia Cecilia; Cagnin, Annachiara; Cappa, Stefano F; Giubilei, Franco; Guarino, Maria; Iavarone, Alessandro; Isella, Valeria; Luca, Antonina; Monastero, Roberto; Pellegrini, Francesca Ferrari; Perini, Marta; Piccoli, Tommaso; Rainero, Innocenzo; Tedeschi, Gioacchino; Marra, Camillo; Caffarra, Paolo, Itel MMSE: a short phone screening test for cognitive decline. Italian Validation study by the SINdem Neuropsychology Working Group «NEUROLOGICAL SCIENCES» , vol. 46 , n. 4 , 2025 , pp. 1617-1627

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