Publications

Authors:

Trinco, Andrea; Romano, Francesco; Invernizzi, Alessandro; Zaffalon, Chiara; Bosello, Francesca; Casati, Stefano; Zicarelli, Federico; D'Introno, Rossella; Staurenghi, Giovanni; Salvetti, Anna Paola

Title:

Punctate Inner Choroidopathy (PIC)-like Reaction in Stage 3 Extensive Macular Atrophy with Pseudodrusen-like Appearance (EMAP)

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

RETINAL CASES & BRIEF REPORTS

ISSN of journal:

1935-1089

N° Volume:

First published online: 15 January 2025

Page numbers:

N/A-N/A

Keyword:

extensive macular atrophy with pseudodrusen-like appearance (EMAP); multimodal imaging; immune dysregulation

Short description of contents:

Purpose: To describe a rare complication in a patient with extensive macular atrophy with pseudodrusen-like appearance (EMAP), suggesting immune dysregulation in advanced stages of the disease. Methods: Case Report. Multimodal imaging -including true-color fundus photography, blue autofluorescence, high-resolution optical coherence tomography (Hi-Res OCT), swept-source OCT angiography, and dye-based angiography- was used to evaluate retinal alterations. Results: A 53-year-old woman with stage 3 EMAP presented with moderately hyperreflective subretinal material co-localizing with a large rupture of the Bruch's membrane (BrM) in the right eye. Multimodal imaging ruled out macular neovascularization, suggesting a diagnosis of punctate inner choroidopathy (PIC)-like reaction. Treatment with oral steroids led to complete regression of the subretinal inflammatory lesion. Conclusions: This case highlights a novel inflammatory complication in EMAP. Our findings emphasize a potential role of immune dysregulation in late-stage EMAP and underscore the value of multimodal imaging in the management and follow-up of these patients.

Web page:

https://dx.doi.org/10.1097/ICB.0000000000001719

Product ID:

143877

Handle IRIS:

11562/1150373

Last Modified:

January 22, 2025

Bibliographic citation:

Trinco, Andrea; Romano, Francesco; Invernizzi, Alessandro; Zaffalon, Chiara; Bosello, Francesca; Casati, Stefano; Zicarelli, Federico; D'Introno, Rossella; Staurenghi, Giovanni; Salvetti, Anna Paola, Punctate Inner Choroidopathy (PIC)-like Reaction in Stage 3 Extensive Macular Atrophy with Pseudodrusen-like Appearance (EMAP) «RETINAL CASES & BRIEF REPORTS» , vol. First published online: 15 January 2025 , 2025 , pp. N/A-N/A

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