Publications

Authors:

Ferraro, Laura; Di Forti, Marta; La Barbera, Daniele; La Cascia, Caterina; Morgan, Craig; Tripoli, Giada; Jongsma, Hannah; Seminerio, Fabio; Sartorio, Crocettarachele; Sideli, Lucia; Tarricone, Ilaria; Carloni, Anna Lisa; Szoke, Andrei; Pignon, Baptiste; Bernardo, Miguel; de Haan, Lieuwe; Arango, Celso; Velthorst, Eva; Gayer-Anderson, Charlotte; Kirkbride, James; Rutten, Bart P F; Lasalvia, Antonio; Tosato, Sarah; Del Ben, Cristina Marta; Menezes, Paulo Rossi; Bobes, Julio; Arrojo, Manuel; Tortelli, Andrea; Jones, Peter; Selten, Jean-Paul; van Os, Jim; Murray, Robin; Quattrone, Diego; Vassos, Evangelos

Title:

Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors

Year:

2025

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

Psychological Medicine

ISSN of journal:

0033-2917

N° Volume:

55

Page numbers:

1-11

Keyword:

IQ; cannabis; childhood abuse; cluster analysis; migration; risk factors

Short description of contents:

Background: Previous studies identified clusters of first-episode psychosis (FEP) patients based on cognition and premorbid adjustment. This study examined a range of socio-environmental risk factors associated with clusters of FEP, aiming a) to compare clusters of FEP and community controls using the Maudsley Environmental Risk Score for psychosis (ERS), a weighted sum of the following risks: paternal age, childhood adversities, cannabis use, and ethnic minority membership; b) to explore the putative differences in specific environmental risk factors in distinguishing within patient clusters and from controls. Methods: A univariable general linear model (GLS) compared the ERS between 1,263 community controls and clusters derived from 802 FEP patients, namely, low (n = 223) and high-cognitive-functioning (n = 205), intermediate (n = 224) and deteriorating (n = 150), from the EU-GEI study. A multivariable GLS compared clusters and controls by different exposures included in the ERS. Results: The ERS was higher in all clusters compared to controls, mostly in the deteriorating (β=2.8, 95% CI 2.3 3.4, η2 = 0.049) and the low-cognitive-functioning cluster (β=2.4, 95% CI 1.9 2.8, η2 = 0.049) and distinguished them from the cluster with high-cognitive-functioning. The deteriorating cluster had higher cannabis exposure (meandifference = 0.48, 95% CI 0.49 0.91) than the intermediate having identical IQ, and more people from an ethnic minority (meandifference = 0.77, 95% CI 0.24 1.29) compared to the high-cognitive-functioning cluster. Conclusions: High exposure to environmental risk factors might result in cognitive impairment and lower-than-expected functioning in individuals at the onset of psychosis. Some patients' trajectories involved risk factors that could be modified by tailored interventions.

Web page:

https://doi.org/10.1017/S0033291724003507

Product ID:

144239

Handle IRIS:

11562/1153928

Last Modified:

February 8, 2025

Bibliographic citation:

Ferraro, Laura; Di Forti, Marta; La Barbera, Daniele; La Cascia, Caterina; Morgan, Craig; Tripoli, Giada; Jongsma, Hannah; Seminerio, Fabio; Sartorio, Crocettarachele; Sideli, Lucia; Tarricone, Ilaria; Carloni, Anna Lisa; Szoke, Andrei; Pignon, Baptiste; Bernardo, Miguel; de Haan, Lieuwe; Arango, Celso; Velthorst, Eva; Gayer-Anderson, Charlotte; Kirkbride, James; Rutten, Bart P F; Lasalvia, Antonio; Tosato, Sarah; Del Ben, Cristina Marta; Menezes, Paulo Rossi; Bobes, Julio; Arrojo, Manuel; Tortelli, Andrea; Jones, Peter; Selten, Jean-Paul; van Os, Jim; Murray, Robin; Quattrone, Diego; Vassos, Evangelos, Cognitive presentation at psychosis onset through premorbid deterioration and exposure to environmental risk factors «Psychological Medicine» , vol. 55 , 2025 , pp. 1-11

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