Pubblicazioni

Autori:

Marignier, Romain; Villacieros-Álvarez, Javier; Espejo, Carmen; Arrambide, Georgin; Fissolo, Nicolás; Gutiérrez, Lucía; Dinoto, Alessandro; Mulero, Patricia; Rubio-Flores, Laura; Nieto, Pablo; Alcalá, Carmen; Meca-Lallana, Jose E; Martínez-Garcia, Pedro; Millán, Jorge; Bernard-Valnet, Raphaël; González, Inés; Orvíz García, Aida; Tellez, Raquel; Navarro, Laura; Presas-Rodríguez, Silvia; Romero-Pinel, Lucía; Martínez-Yélamos, Sergio; Cuello, Juan Pablo; Alonso Torres, Ana Maria; Piñar, Raquel; Álvarez Bravo, Gary; Benyahya, Lakhdar; Trouillet-Assant, Sophie; Dyon-Tafani, Virginie; Froment Tilikete, Caroline; Ruet, Aurelie; Bourre, Bertrand; Deschamps, Romain; Papeix, Caroline; Maillart, Elisabeth; Kerschen, Philippe; Ayrignac, Xavier; Rovira, Alex; Auger, Cristina; Audoin, Bertrand; Montalban, Xavier; Tintore, Mar; Mariotto, Sara; Cobo-Calvo, Alvaro

Titolo:

Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study

Anno:

2025

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Neurology, neurosurgery and psychiatry

ISSN Rivista:

0022-3050

N° Volume:

96

Numero o Fascicolo:

9

Intervallo pagine:

884-892

Parole chiave:

MULTIPLE SCLEROSIS; MYELIN; NEUROBIOLOGY; NEUROIMMUNOLOGY

Breve descrizione dei contenuti:

Background Serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP) have emerged as important biomarkers in multiple sclerosis (MS) and aquaporin-4 seropositive neuromyelitis optica spectrum disorder (AQP4-NMOSD). However, their interest in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) remains unclear. Our aim was to characterise sNfL and sGFAP profile and analyse their usefulness in predicting relapses and disability in MOGAD. Methods Retrospective study of adult MOGAD patients with serum samples collected at baseline (<= 3 months from disease onset) and follow-up (>6 months from baseline sample). sNfL and sGFAP were analysed using Simoa HD-1, and values were compared across time-points. The association between biomarkers and clinical variables and their predictive value for disability and relapses were analysed. Results Eighty-nine MOGAD patients were included. Baseline sNfL and sGFAP values were high at baseline and decreased over time (p<0.001, p=0.027, respectively). sNfL and sGFAP values were associated with Expanded Disability Status Scale (EDSS) at attacks (beta 0.15 (0.06; 0.25), p=0.002; beta 0.14 (0.07; 0.21), p<0.001, respectively) and were lower in optic neuritis presentations (beta -0.69 (-1.18; -0.19), p=0.007; beta -0.42 (-0.76; -0.08), p=0.016). Biomarker deltas[Delta] (baseline values - second samples values) were associated with Delta EDSS (initial EDSS - final EDSS) (Delta sNfL beta 0.52 (0.01; 1.04), p=0.046; Delta sGFAP beta 1.07 (0.38; 1.75), p=0.003). Finally, sNfL values independently predicted the risk of relapses (HR 2.06 (1.41; 3.01), p<0.001). Conclusions Our results on sNfL and sGFAP suggest initial neuro-axonal and astrocytic damage in MOGAD and the utility of these biomarkers at onset and follow-up in predicting clinical recovery and relapses.

Pagina Web:

https://doi.org/10.1136/jnnp-2024-335137

Id prodotto:

147960

Handle IRIS:

11562/1173167

ultima modifica:

25 ottobre 2025

Citazione bibliografica:

Marignier, Romain; Villacieros-Álvarez, Javier; Espejo, Carmen; Arrambide, Georgin; Fissolo, Nicolás; Gutiérrez, Lucía; Dinoto, Alessandro; Mulero, Patricia; Rubio-Flores, Laura; Nieto, Pablo; Alcalá, Carmen; Meca-Lallana, Jose E; Martínez-Garcia, Pedro; Millán, Jorge; Bernard-Valnet, Raphaël; González, Inés; Orvíz García, Aida; Tellez, Raquel; Navarro, Laura; Presas-Rodríguez, Silvia; Romero-Pinel, Lucía; Martínez-Yélamos, Sergio; Cuello, Juan Pablo; Alonso Torres, Ana Maria; Piñar, Raquel; Álvarez Bravo, Gary; Benyahya, Lakhdar; Trouillet-Assant, Sophie; Dyon-Tafani, Virginie; Froment Tilikete, Caroline; Ruet, Aurelie; Bourre, Bertrand; Deschamps, Romain; Papeix, Caroline; Maillart, Elisabeth; Kerschen, Philippe; Ayrignac, Xavier; Rovira, Alex; Auger, Cristina; Audoin, Bertrand; Montalban, Xavier; Tintore, Mar; Mariotto, Sara; Cobo-Calvo, Alvaro, Assessment of neuronal and glial serum biomarkers in myelin oligodendrocyte glycoprotein antibody-associated disease: the MULTIMOGAD study «Journal of Neurology, neurosurgery and psychiatry» , vol. 96 , n. 9 , 2025 , pp. 884-892

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo