Pubblicazioni

Autori:

Michelson, S; Dal Monte, P; Zipeto, D; Bodaghi, B; Laurent, L; Oberlin, E; Arenzana-Seisdedos, F; Virelizier, Jl; Landini, Mp

Titolo:

Modulation of RANTES production by human cytomegalovirus (CMV) infection of fibroblasts.

Anno:

1997

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Journal of Virology

ISSN Rivista:

0022-538X

N° Volume:

71

Numero o Fascicolo:

9

Intervallo pagine:

6495-6500

Parole chiave:

Rantes cytomegalovirus fibroblasts

Breve descrizione dei contenuti:

Chemokines play a major role in inflammatory responses and affect hematopoiesis both negatively and positively. We show that fresh isolates and laboratory strains (Towne and Ad-169) of human cytomegalovirus (HCMV) induce production of the CC chemokine RANTES in fibroblasts. Induction of extracellular RANTES production occurred as early as 8 h after infection, peaked around 24 h after infection, and was almost undetectable by 48 and 72 h. Upregulation occurred in the absence of viral DNA synthesis, suggesting that it was due to immediate-early-early HCMV gene expression. CMV infection stimulated RANTES transcription, since reverse transcription-PCR detected a sharp increase in RANTES RNA which persisted even when extracellular RANTES was no longer detected. Induction of RANTES in fibroblasts was not due to prior induction of tumor necrosis factor alpha or interleukin 1 beta. Down-regulation required an active viral genome. Decrease of RANTES in culture supernatants may be associated with the appearance of the HCMV CC chemokine receptor US28, since we show that this gene is transcribed as early as 8 h after infection. Modulation of CC chemokine production early during CMV infection might have a regulatory effect on viral replication, as well as affect immune surveillance.

Pagina Web:

http://jvi.asm.org/content/71/9/6495.long
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC191924/?tool=pubmed

Id prodotto:

35256

Handle IRIS:

11562/236846

depositato il:

22 giugno 2012

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Michelson, S; Dal Monte, P; Zipeto, D; Bodaghi, B; Laurent, L; Oberlin, E; Arenzana-Seisdedos, F; Virelizier, Jl; Landini, Mp, Modulation of RANTES production by human cytomegalovirus (CMV) infection of fibroblasts. «Journal of Virology» , vol. 71 , n. 9 , 1997 , pp. 6495-6500

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