Pubblicazioni

Autori:

Valenti, Maria Teresa; DALLE CARBONARE, Luca Giuseppe; Bertoldo, Francesco; Donatelli, Luca; LO CASCIO, Vincenzo

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Titolo:

The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells

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Anno:

2008

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Tipologia prodotto:

Articolo in Rivista

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Tipologia ANVUR:

Articolo su rivista

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Lingua:

Inglese

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Formato:

A Stampa

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Referee:

Sì

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Nome rivista:

European Journal of Pharmacology

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ISSN Rivista:

0014-2999

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N° Volume:

580

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Numero o Fascicolo:

1-2

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Intervallo pagine:

36-42

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Parole chiave:

hTERT expression; amino-bisphosphonate; Prostate Cancer

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Breve descrizione dei contenuti:

interference with themevalonate pathway. In addition, it is well known that gene expression of hTERT, the catalytic subunit of the telomerase, is elevated in prostatic cancer. In the prostate cancer cell lines we investigated the effects on hTERT gene expression of several bisphosphonates.We also evaluated whether the observed levels of expression were affected by the exposure to an analogue of the geranylgeranylpyrophosphate, the geranylgeraniol used to recover the mevalonate pathway. Our results showed that the amino-bisphosphonates down-regulate hTERT gene expression and that combined treatment with geranylgeraniol and zoledronate was able to revert only partially the effects on viability; on the contrary, hTERT gene down-regulation was not affected by the restoration of the mevalonate pathway. These results support the hypothesis that prostatic cancer cells are targeted by aminobisphosphonates also through a different mechanism from the mevalonate pathway.

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Id prodotto:

40822

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Handle IRIS:

11562/316931

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depositato il:

26 maggio 2008

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ultima modifica:

2 dicembre 2022

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Citazione bibliografica:

Valenti, Maria Teresa; DALLE CARBONARE, Luca Giuseppe; Bertoldo, Francesco; Donatelli, Luca; LO CASCIO, Vincenzo, The effects on hTERT gene expression is an additional mechanism of amino-bisphosphonates in prostatic cancer cells «European Journal of Pharmacology» , vol. 580 , n. 1-2 , 2008 , pp. 36-42

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