Pubblicazioni

Autori:

Valenti, Maria Teresa; DALLE CARBONARE, Luca Giuseppe; Donatelli, Luca; Bertoldo, Francesco; Giovanazzi, Benedetta; Caliari, Francesco; LO CASCIO, Vincenzo

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Titolo:

STEAP mRNA detection in serum of patients with solid tumours.

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Anno:

2009

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Tipologia prodotto:

Articolo in Rivista

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Tipologia ANVUR:

Articolo su rivista

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Lingua:

Inglese

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Referee:

Sì

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Nome rivista:

Cancer Letters

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ISSN Rivista:

0304-3835

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N° Volume:

273

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Numero o Fascicolo:

1

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Intervallo pagine:

122-126

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Parole chiave:

STEAP; cancer; serum

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Breve descrizione dei contenuti:

STEAP was identified by the strategy of suppression subtractive hybridizations in Los Angeles prostate cancer xenografts. It is expressed in prostate and other cancers, and not in most normal tissue; it can be used as a marker to evaluate biological samples from individuals suspected of having a disease associated with STEAP dysregulation, such as cancers, and may provide prognostic information useful in defining appropriate therapeutic options. The aim of this study was to test the STEAP mRNA detection in the serum of patients with different malignant tumours by using Real-Time reverse transcription PCR. The results were compared with biological samples obtained by age-matched non-malignant donors. Our data demonstrated that STEAP mRNA is detectable in serum of patients with different solid tumours whereas it is not amplifiable in non-malignant donors. This marker revealed with the molecular method of quantitative PCR in serum, may be useful to discriminate normal and cancer patients.

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Id prodotto:

55091

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Handle IRIS:

11562/323868

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depositato il:

14 luglio 2012

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ultima modifica:

29 novembre 2022

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Citazione bibliografica:

Valenti, Maria Teresa; DALLE CARBONARE, Luca Giuseppe; Donatelli, Luca; Bertoldo, Francesco; Giovanazzi, Benedetta; Caliari, Francesco; LO CASCIO, Vincenzo, STEAP mRNA detection in serum of patients with solid tumours. «Cancer Letters» , vol. 273 , n. 1 , 2009 , pp. 122-126

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