- Authors:
-
Romanelli, Maria; Lorenzi, Pamela; Sangalli, Antonella; Diani, Erica; Mottes, Monica
- Title:
-
Characterization and functional analysis of cis-acting elements of the human farnesyl diphosphate synthetase (FDPS) gene 5' flanking region.
- Year:
-
2009
- Type of item:
-
Articolo in Rivista
- Tipologia ANVUR:
- Articolo su rivista
- Language:
-
Inglese
- Format:
-
A Stampa
- Referee:
-
Sì
- Name of journal:
- Genomics
- ISSN of journal:
- 0888-7543
- N° Volume:
-
93
- Number or Folder:
-
3
- Page numbers:
-
227-234
- Keyword:
-
FPP; promoter analysis; farnesyl diphospate synthase; FDPS
- Short description of contents:
- Farnesyl diphosphate synthetase (FDPS) is a key enzyme in the isoprenoid pathway responsible for cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones, whose expression is regulated by phorbol esters and polyunsaturated fatty acids. Genomic comparison of the 5' upstream sequence of the FDPS genes identifies conserved binding sites for NF-Y, SP1, SRE3, and YY1 regulatory elements in rat, mouse, dog and chimpanzee. Two additional specific consensus sequences, upstream of the core promoter that had not been analysed previously, are shared only by human and chimpanzee genomes. The work presented here aimed at characterizing these genomic sequence elements in the human FDPS promoter region and their contribution to gene expression. We have characterized functionally the minimal basal promoter of the human FDPS gene by means of deletion mutants and we have identified two cis-acting elements which modulate the FDPS gene expression and are recognized by Pax5 and OCT-1 transcription factors.
- Web page:
-
http://www.ncbi.nlm.nih.gov/pubmed/19056481
- Product ID:
-
48760
- Handle IRIS:
-
11562/324833
- Deposited On:
-
February 24, 2012
- Last Modified:
-
October 2, 2022
- Bibliographic citation:
-
Romanelli, Maria; Lorenzi, Pamela; Sangalli, Antonella; Diani, Erica; Mottes, Monica,
Characterization and functional analysis of cis-acting elements of the human farnesyl diphosphate synthetase (FDPS) gene 5' flanking region.
«Genomics»
, vol.
93
, n.
3
,
2009
,
pp. 227-234
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