Pubblicazioni

Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche  (2009)

Autori:
Bifari, Francesco; Decimo, Ilaria; Chiamulera, Cristiano; Bersan, Emanuela; Malpeli, Giorgio; Johansson, Jan Evert; Lisi, Veronica; Bonetti, Bruno; Fumagalli, Guido Francesco; Pizzolo, Giovanni; Krampera, Mauro

Titolo:
Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche

Anno:
2009

Tipologia prodotto:
Articolo in Rivista

Tipologia ANVUR:
Articolo su rivista

Lingua:
Inglese

Formato:
A Stampa

Referee:

Nome rivista:
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ISSN Rivista:
1582-1838

N° Volume:
13

Numero o Fascicolo:
9B

Intervallo pagine:
3195-3208

Parole chiave:
neural stem cells; leptomeninges; stem cell niche; neuronal differentiation

Breve descrizione dei contenuti:
Abstract Stem cells capable of generating neural differentiated cells are recognized by the expression of nestin and reside in specific regions of the brain, namely hippocampus, subventricular zone (SVZ), and olfactory bulb. For other brain structures, such as leptomeninges, which contribute to the correct cortex development and functions, there is no evidence so far that they may contain stem/precursor cells. In this work, we show for the first time that nestin-positive cells are present in rat leptomeninges during development up to adulthood. The newly identified nestin-positive cells can be extracted and expanded in vitro both as neurospheres, displaying high similarity with SVZ-derived neural stem cells, and as homogeneous cell population with stem cell features. In vitro expanded stem cell population can differentiate with high efficiency into excitable cells with neuronal phenotype and morphology. Once injected into adult brain, these cells survive and differentiate into neurons, thus showing that their neuronal differentiation potential is operational also in vivo. In conclusion, our data provide evidence that a specific population of immature cells endowed of neuronal differentiation potential is resident in the leptomeninges throughout the life. As leptomemniges cover the entire central nervous system, these findings could have relevant implications for studies on cortical development and for regenerative medicine applied to neurological disorders.

Id prodotto:
48840

Handle IRIS:
11562/327452

depositato il:
20 gennaio 2010

ultima modifica:
16 novembre 2022

Citazione bibliografica:
Bifari, Francesco; Decimo, Ilaria; Chiamulera, Cristiano; Bersan, Emanuela; Malpeli, Giorgio; Johansson, Jan Evert; Lisi, Veronica; Bonetti, Bruno; Fumagalli, Guido Francesco; Pizzolo, Giovanni; Krampera, Mauro, Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche «JOURNAL OF CELLULAR AND MOLECULAR MEDICINE» , vol. 13 , n. 9B2009pp. 3195-3208

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo IRIS

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