Publications

Authors:

Giarola, A; Auber, Alessia; Chiamulera, Cristiano

Title:

Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats

Year:

2011

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

BEHAVIOURAL PHARMACOLOGY

ISSN of journal:

0955-8810

N° Volume:

22

Number or Folder:

1

:

Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320

Page numbers:

1-6

Keyword:

acetylcholinesterase inhibitor; drug discrimination; galantamine; nicotine; physostigmine; rat; tacrin

Short description of contents:

Acetylcholinesterase inhibitors (AChE-Is), galantamine, physostigmine and tacrine, enhance central levels of synaptic acetylcholine. Galantamine and physostigmine, but not tacrine, exhibit allosteric potentiation ligand (APL) properties on nicotinic acetylcholine receptors. The purpose of this study was to investigate whether AChE-Is with nicotinic acetylcholine receptor-positive allosteric modulator properties generalize to the discriminative stimulus effect of nicotine in rats. A two-lever operant conditioning paradigm was used in which rats were trained to discriminate nicotine (0.2 mg/kg/ml intraperitoneally) from saline. After training, generalization tests were carried out with galantamine (1, 3 or 5 mg/kg intraperitoneally), physostigmine (0.05, 0.1 or 0.2 mg/kg subcutaneously) or tacrine (0.625, 1.25 or 2.5 mg/kg subcutaneously) given as a single presession administration. Galantamine, physostigmine or tacrine produced a partial generalization of 62.2%, 55.1% or 43.6% , respectively, on the nicotine-appropriate lever compared with 100% partial generalization induced by the nicotine-training dose. High doses of galantamine, physostigmine or tacrine produced small but significant decreases in operant response rate, suggesting a possible underestimation of the degree of generalization. Our study showed that these three AChE-Is partially generalized to the nicotine stimulus without a significant distinction between AChE-Is with or without APL properties. These findings suggest that the APL property is not necessary for inducing nicotine-like effects in vivo in this behavioural paradigm.

Product ID:

58411

Handle IRIS:

11562/346588

Deposited On:

December 6, 2010

Last Modified:

November 15, 2022

Bibliographic citation:

Giarola, A; Auber, Alessia; Chiamulera, Cristiano, Acetylcholinesterase inhibitors partially generalize to nicotine discriminative stimulus effect in rats «BEHAVIOURAL PHARMACOLOGY» , vol. 22 , n. 1 , 2011 , pp. 1-6

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo