Pubblicazioni

Autori:

Andreone, N; Tansella, Michele; Cerini, Roberto; Versace, A; Rambaldelli, Gianluca; Perlini, Cinzia; Dusi, Nicola; Pelizza, L; Balestrieri, M; Barbui, C; Nosè, M; Gasparini, A; Brambilla, P.

Titolo:

Cortical white-matter microstructure in schizophrenia. Diffusion imaging study.

Anno:

2007

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Referee:

No

Nome rivista:

British Journal of Psychiatry

ISSN Rivista:

0007-1250

N° Volume:

191

Intervallo pagine:

113-119

Parole chiave:

Adult; Brain Diseases; Case-Control Studies; Cerebral Cortex; Diffusion Magnetic Resonance Imaging; Female; Humans; Male; Middle Aged; Schizophrenia

Breve descrizione dei contenuti:

Several, although not all, of the previous small diffusion-weighted imaging (DWI) studies have shown cortical white-matter disruption in schizophrenia.To investigate cortical white-matter microstructure with DWI in a large community-based sample of people with schizophrenia.Sixty-eight people with schizophrenia and 64 healthy controls underwent a session of DWI to obtain the apparent diffusion coefficient (ADC) of white-matter water molecules. Regions of interest were placed in cortical lobes.Compared with controls, the schizophrenia group had significantly greater ADCs in frontal, temporal and occipital white matter (analysis of covariance, P < 0.05).Our findings confirm the presence of cortical white-matter microstructure disruption in frontal and temporo-occipital lobes in the largest sample of people with schizophrenia thus for studied with this technique. Future brain imaging studies, together with genetic investigations, should further explore white-matter integrity and genes encoding myelin-related protein expression in people with first-episode schizophrenia and those at high risk of developing the disorder.

Id prodotto:

60238

Handle IRIS:

11562/348915

ultima modifica:

16 novembre 2022

Citazione bibliografica:

Andreone, N; Tansella, Michele; Cerini, Roberto; Versace, A; Rambaldelli, Gianluca; Perlini, Cinzia; Dusi, Nicola; Pelizza, L; Balestrieri, M; Barbui, C; Nosè, M; Gasparini, A; Brambilla, P., Cortical white-matter microstructure in schizophrenia. Diffusion imaging study. «British Journal of Psychiatry» , vol. 191 , 2007 , pp. 113-119

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