Publications

Authors:

Brambilla, P; Cerruti, Stefania; Bellani, Marcella; Perlini, Cinzia; Ferro, Adele; Marinelli, Veronica; Giusto, D; Tomelleri, Luisa; Rambaldelli, Gianluca; Tansella, Michele; Diwadkar, Va

Title:

Shared impairment in associative learning in schizophrenia and bipolar disorder

Year:

2011

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

Progress in Neuro Psychopharmacology

ISSN of journal:

0278-5846

Page numbers:

1093-1099

Keyword:

Glutamatergic system; Hippocampus; Memory; Neuropsychology; Plasticity

Short description of contents:

BACKGROUND: Schizophrenia (SCZ) and bipolar disorder (BD) share some cognitive commonalities. However, the role of associative learning, which is a cornerstone of human cognition mainly relying on hippocampus, has been under-investigated. We assessed behavioral performance during associative learning in a group of SCZ, BD and healthy controls (HC). METHODS: Nineteen patients with SCZ (36±8.1years; 13 males, 6 females; all Caucasians), 14 patients with BD (41±9.6years; 5 males, 9 females; all Caucasians) and 45 HC (27.7±6.9years; 18 males, 27 females; all Caucasians) were studied. Learning was assessed using an established object-location paired-associative learning paradigm. Subjects learned associations between nine equi-familiar common objects and locations in a nine-location grid. Performance data were analyzed in a repeated measures analysis of variance with time (repeated) and group as factors. RESULTS: Learning curves (performance=1-e(-k⁎time)) fitted to average performance data in the three groups revealed lower learning rates in SCZ and BD (k=0.17 and k=0.34) than HC (k=0.78). Significant effects of group (F=11.05, p<0.001) and time (F=122.06, p<0.001) on learning performance were observed. CONCLUSIONS: Our study showed that associative learning is impaired in both SCZ and BD, being potentially not affected by medication. Future studies should investigate the neural substrates of learning deficits in SCZ and BD, particularly focusing on hippocampus function and glutamatergic transmission.

Product ID:

60258

Handle IRIS:

11562/350788

Deposited On:

April 11, 2011

Last Modified:

December 1, 2022

Bibliographic citation:

Brambilla, P; Cerruti, Stefania; Bellani, Marcella; Perlini, Cinzia; Ferro, Adele; Marinelli, Veronica; Giusto, D; Tomelleri, Luisa; Rambaldelli, Gianluca; Tansella, Michele; Diwadkar, Va, Shared impairment in associative learning in schizophrenia and bipolar disorder «Progress in Neuro Psychopharmacology» , 2011 , pp. 1093-1099

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