Pubblicazioni

Autori:

Brambilla, P; Cerruti, Stefania; Bellani, Marcella; Perlini, Cinzia; Ferro, Adele; Marinelli, Veronica; Giusto, D; Tomelleri, Luisa; Rambaldelli, Gianluca; Tansella, Michele; Diwadkar, Va

Titolo:

Shared impairment in associative learning in schizophrenia and bipolar disorder

Anno:

2011

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

Progress in Neuro Psychopharmacology

ISSN Rivista:

0278-5846

Intervallo pagine:

1093-1099

Parole chiave:

Glutamatergic system; Hippocampus; Memory; Neuropsychology; Plasticity

Breve descrizione dei contenuti:

BACKGROUND: Schizophrenia (SCZ) and bipolar disorder (BD) share some cognitive commonalities. However, the role of associative learning, which is a cornerstone of human cognition mainly relying on hippocampus, has been under-investigated. We assessed behavioral performance during associative learning in a group of SCZ, BD and healthy controls (HC). METHODS: Nineteen patients with SCZ (36±8.1years; 13 males, 6 females; all Caucasians), 14 patients with BD (41±9.6years; 5 males, 9 females; all Caucasians) and 45 HC (27.7±6.9years; 18 males, 27 females; all Caucasians) were studied. Learning was assessed using an established object-location paired-associative learning paradigm. Subjects learned associations between nine equi-familiar common objects and locations in a nine-location grid. Performance data were analyzed in a repeated measures analysis of variance with time (repeated) and group as factors. RESULTS: Learning curves (performance=1-e(-k⁎time)) fitted to average performance data in the three groups revealed lower learning rates in SCZ and BD (k=0.17 and k=0.34) than HC (k=0.78). Significant effects of group (F=11.05, p<0.001) and time (F=122.06, p<0.001) on learning performance were observed. CONCLUSIONS: Our study showed that associative learning is impaired in both SCZ and BD, being potentially not affected by medication. Future studies should investigate the neural substrates of learning deficits in SCZ and BD, particularly focusing on hippocampus function and glutamatergic transmission.

Id prodotto:

60258

Handle IRIS:

11562/350788

depositato il:

11 aprile 2011

ultima modifica:

1 dicembre 2022

Citazione bibliografica:

Brambilla, P; Cerruti, Stefania; Bellani, Marcella; Perlini, Cinzia; Ferro, Adele; Marinelli, Veronica; Giusto, D; Tomelleri, Luisa; Rambaldelli, Gianluca; Tansella, Michele; Diwadkar, Va, Shared impairment in associative learning in schizophrenia and bipolar disorder «Progress in Neuro Psychopharmacology» , 2011 , pp. 1093-1099

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