Publications

Authors:

Cappellari, Manuel; Deluca, Cristina; Tinazzi, Michele; Tomelleri, Giampaolo; Carletti, Monica; Fiaschi, Antonio; Bovi, Paolo; Moretto, Giuseppe

Title:

Does statin in the acute phase of ischemic stroke improve outcome after intravenous thrombolysis? A retrospective study.

Year:

2011

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of the Neurological Sciences

ISSN of journal:

0022-510X

N° Volume:

308

Number or Folder:

1-2

Page numbers:

128-134

Keyword:

acute ischemic stroke outcome; statin; thrombolysis

Short description of contents:

BACKGROUND: In recent years, the medical literature has shown that statin treatment before and in the acute phase of ischemic stroke has a positive impact on outcome. The possible effect of statins during the acute phase has never been assessed in thrombolysed patients, and the few studies investigating a possible association between prior statin use and outcome after thrombolysis have reported controversial results. The aim of the present study was to assess whether statin treatment started in the acute phase of stroke (within 24h) or before stroke and continued during the acute phase may influence short- and long-term outcome in patients receiving intravenous (IV) thrombolysis. METHODS: We conducted a retrospective analysis of 250 patients treated with IV thrombolysis. Outcome measures were 3-month good functional outcome (modified Rankin Scale ≤2); neurological improvement (reduction ≥4 points on the National Institutes of Health Stroke Scale [NIHSS]) between 24 and 72h; and symptomatic intracerebral hemorrhage (brain hematoma associated with NIHSS deterioration ≥4 points) within 72h. RESULTS: Multivariate analysis showed that statin treatment started in the acute phase of stroke was associated with both good functional outcome (OR: 6.18; 95\% CI: 1.43-26.62; P=0.015) and neurological improvement (OR: 9.47; 95\% CI: 1.98-45.37; P=0.005), whereas statin treatment started before stroke and continued in the acute phase was associated with symptomatic intracerebral hemorrhage (OR: 6.65; 95\% CI: 1.58-29.12; P=0.010). CONCLUSIONS: Our data suggest that statin treatment started within 24h after IV thrombolysis, but not statin treatment started before stroke and continued in the acute phase, may improve short- and long-term outcome.

Product ID:

61413

Handle IRIS:

11562/355586

Deposited On:

August 14, 2011

Last Modified:

November 14, 2022

Bibliographic citation:

Cappellari, Manuel; Deluca, Cristina; Tinazzi, Michele; Tomelleri, Giampaolo; Carletti, Monica; Fiaschi, Antonio; Bovi, Paolo; Moretto, Giuseppe, Does statin in the acute phase of ischemic stroke improve outcome after intravenous thrombolysis? A retrospective study. «Journal of the Neurological Sciences» , vol. 308 , n. 1-2 , 2011 , pp. 128-134

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