Pubblicazioni

Autori:

Turci, Marco; Racchiolli, Pierpaolo; Ziglio, Serena; Astone, Dalila; Blanco, A.; Zipeto, Donato

Titolo:

HLA-C associates with Env and Increases HIV-1 infectivity

Anno:

2011

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

No

Nome rivista:

JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

ISSN Rivista:

1525-4135

Numero o Fascicolo:

56

Editore:

Lippincott, Williams & Wilkins:530 Walnut Street:Philadelphia, PA 19106:(800)638-3030, (301)223-2300, EMAIL: orders@lww.com, INTERNET: http://www.lww.com, Fax: (301)223-2320, (301)223-2320

Intervallo pagine:

65-65

Parole chiave:

HIV-1 AIDS HLA-C

Breve descrizione dei contenuti:

Host cell proteins are specifically incorpo- rated into HIV-1 envelope during budding. Virionic HLA- C reduces HIV-1 susceptibility to neutralizing antibodies (Cosma 1999). A polymorphism in the 5’ region of the HLA- C gene has been associated to individual variations in set point viral loads (Fellay 2007), suggesting a role of HLA-C expression levels in modulating HIV-1 infectivity. We have reported (Matucci 2008; Baroni 2010) that HLA-C in the HIV-1 envelope associates to Env increasing viral infectivity of both R5 and X4 tropic viruses. The purpose of this study is to elucidate this interaction and exploit it for generating new immunogens capable of conferring protective immunity.

Pagina Web:

http://journals.lww.com/jaids/Fulltext/2011/04002/157a_HLA_C_Associates_with_Env_and_Increases_HIV_1.54.aspx

Id prodotto:

61970

Handle IRIS:

11562/363237

depositato il:

21 giugno 2012

ultima modifica:

1 novembre 2022

Citazione bibliografica:

Turci, Marco; Racchiolli, Pierpaolo; Ziglio, Serena; Astone, Dalila; Blanco, A.; Zipeto, Donato, HLA-C associates with Env and Increases HIV-1 infectivity «JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES» , n. 56 , 2011 , pp. 65-65

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