Pubblicazioni

Autori:

Bertazzoni, U.; Turci, M.; Avesani, F.; DI GENNARO, Gianfranco; Bidoia, C.; Romanelli, Maria

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Titolo:

Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences.

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Anno:

2011

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Tipologia prodotto:

Articolo in Rivista

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Tipologia ANVUR:

Articolo su rivista

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Lingua:

Inglese

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Formato:

Elettronico

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Referee:

Sì

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Nome rivista:

VIRUSES

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ISSN Rivista:

1999-4915

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N° Volume:

3

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Numero o Fascicolo:

5

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Intervallo pagine:

541-560

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Parole chiave:

HTLV; Tax-1; Tax-2; signal transduction; cellular localization; post-translational modifications; NF-κB; PDZ binding motif

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Breve descrizione dei contenuti:

Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ in their cellular localization and in their interaction pattern with cellular factors? In this review, we summarize Tax-1 and Tax-2 structural and phenotypic properties, their interaction with factors involved in signal transduction and their localization-related behavior within the cell. Special attention will be given to the distinctions between Tax-1 and Tax-2 that likely play an important role in their transactivation activity.

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Pagina Web:

http://www.ncbi.nlm.nih.gov/pubmed

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Id prodotto:

63738

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Handle IRIS:

11562/373052

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depositato il:

14 novembre 2011

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ultima modifica:

15 novembre 2022

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Citazione bibliografica:

Bertazzoni, U.; Turci, M.; Avesani, F.; DI GENNARO, Gianfranco; Bidoia, C.; Romanelli, Maria, Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences. «VIRUSES» , vol. 3 , n. 5 , 2011 , pp. 541-560

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