Pubblicazioni

Autori:

Bertazzoni, U.; Turci, M.; Avesani, F.; DI GENNARO, Gianfranco; Bidoia, C.; Romanelli, Maria

Titolo:

Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences.

Anno:

2011

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

VIRUSES

ISSN Rivista:

1999-4915

N° Volume:

3

Numero o Fascicolo:

5

Intervallo pagine:

541-560

Parole chiave:

HTLV; Tax-1; Tax-2; signal transduction; cellular localization; post-translational modifications; NF-κB; PDZ binding motif

Breve descrizione dei contenuti:

Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ in their cellular localization and in their interaction pattern with cellular factors? In this review, we summarize Tax-1 and Tax-2 structural and phenotypic properties, their interaction with factors involved in signal transduction and their localization-related behavior within the cell. Special attention will be given to the distinctions between Tax-1 and Tax-2 that likely play an important role in their transactivation activity.

Pagina Web:

http://www.ncbi.nlm.nih.gov/pubmed

Id prodotto:

63738

Handle IRIS:

11562/373052

depositato il:

14 novembre 2011

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Bertazzoni, U.; Turci, M.; Avesani, F.; DI GENNARO, Gianfranco; Bidoia, C.; Romanelli, Maria, Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences. «VIRUSES» , vol. 3 , n. 5 , 2011 , pp. 541-560

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