Publications

Authors:

Brigo, Francesco; Balter, Rita; Marradi, P.; Ferlisi, Monica; Zaccaron, A.; Fiaschi, Antonio; Frasson, E.; Bertolasi, Laura

Title:

Vincristine-related neuropathy versus acute inflammatory demyelinating polyradiculoneuropathy in children with acute lymphoblastic leukemia.

Year:

2012

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

European Journal of Paediatric Neurology

ISSN of journal:

0883-0738

N° Volume:

27

Number or Folder:

7

:

Saunders

Page numbers:

867-874

Keyword:

Acute inflammatory demyelinating polyradiculoneuropathy; acute lymphoblastic leukemia; electroneurography; chemotherapy; intravenous immunoglobulin; neurophysiological studies; vincristine-induced neuropathy

Short description of contents:

The objective of this study was to evaluate whether electroneurography could help in differentiating between vincristine-induced neuropathy and acute inflammatory demyelinating polyradiculoneuropathy. We performed electroneurography in 7 children from September 2006 to March 2009 admitted to receive chemotherapy including vincristine for acute lymphoblastic leukemia, in whom severe acute limb weakness developed, suggesting vincristine-induced neuropathy. Three of 7 patients had electroneurography, suggesting acute inflammatory demyelinating polyradiculoneuropathy. They received intravenous immunoglobulins without discontinuing chemotherapy, and within 10 days their electroclinical conditions improved. Although electroneurography showed only absent F waves, preventing us from reaching a definitive neurophysiological diagnosis of acute inflammatory demyelinating polyradiculoneuropathy, children's presenting clinical manifestations, their disease course, and rapid and complete recovery after intravenous immunoglobulins argued strongly in its favor. A prompt, correct differential diagnosis of vincristine neuropathy and acute inflammatory demyelinating polyradiculoneuropathy in patients with acute lymphoblastic leukemia receiving vincristine is essential to improve disease outcome and prolong life expectancy.

Web page:

http://dx.doi.org/10.1177/0883073811428379

Product ID:

67819

Handle IRIS:

11562/386436

Deposited On:

June 28, 2012

Last Modified:

November 15, 2022

Bibliographic citation:

Brigo, Francesco; Balter, Rita; Marradi, P.; Ferlisi, Monica; Zaccaron, A.; Fiaschi, Antonio; Frasson, E.; Bertolasi, Laura, Vincristine-related neuropathy versus acute inflammatory demyelinating polyradiculoneuropathy in children with acute lymphoblastic leukemia. «European Journal of Paediatric Neurology» , vol. 27 , n. 7 , 2012 , pp. 867-874

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo