Publications

Authors:

Köttgen, A; Albrecht, E; Teumer, A; Vitart, V; Krumsiek, J; Hundertmark, C; Pistis, G; Ruggiero, D; O'Seaghdha, Cm; Haller, T; Yang, Q; Tanaka, T; Johnson, Ad; Kutalik, Z; Smith, Av; Shi, J; Struchalin, M; Middelberg, Rp; Brown, Mj; Gaffo, Al; Pirastu, N; Li, G; Hayward, C; Zemunik, T; Huffman, J; Yengo, L; Zhao, Jh; Demirkan, A; Feitosa, Mf; Liu, X; Malerba, Giovanni; Lopez, Lm; van der Harst, P; Li, X; Kleber, Me; Hicks, Aa; Nolte, Im; Johansson, A; Murgia, F; Wild, Sh; Bakker, Sj; Peden, Jf; Dehghan, A; Steri, M; Tenesa, A; Lagou, V; Salo, P; Mangino, M; Rose, Lm; Lehtimäki, T; Woodward, Om; Okada, Y; Tin, A; Müller, C; Oldmeadow, C; Putku, M; Czamara, D; Kraft, P; Frogheri, L; Thun, Ga; Grotevendt, A; Gislason, Gk; Harris, Tb; Launer, Lj; Mcardle, P; Shuldiner, Ar; Boerwinkle, E; Coresh, J; Schmidt, H; Schallert, M; Martin, Ng; Montgomery, Gw; Kubo, M; Nakamura, Y; Tanaka, T; Munroe, Pb; Samani, Nj; Jacobs DR, Jr; Liu, K; D'Adamo, P; Ulivi, S; Rotter, Ji; Psaty, Bm; Vollenweider, P; Waeber, G; Campbell, S; Devuyst, O; Navarro, P; Kolcic, I; Hastie, N; Balkau, B; Froguel, P; Esko, T; Salumets, A; Khaw, Kt; Langenberg, C; Wareham, Nj; Isaacs, A; Kraja, A; Zhang, Q; Wild, Ps; Scott, Rj; Holliday, Eg; Org, E; Viigimaa, M; Bandinelli, S; Metter, Je; Lupo, Antonio; Trabetti, Elisabetta; Sorice, R; Döring, A; Lattka, E; Strauch, K; Theis, F; Waldenberger, M; Wichmann, He; Davies, G; Gow, Aj; Bruinenberg, M; LifeLines Cohort, Study; Stolk, Rp; Kooner, Js; Zhang, W; Winkelmann, Br; Boehm, Bo; Lucae, S; Penninx, Bw; Smit, Jh; Curhan, G; Mudgal, P; Plenge, Rm; Portas, L; Persico, I; Kirin, M; Wilson, Jf; Mateo Leach, I; van Gilst, Wh; Goel, A; Ongen, H; Hofman, A; Rivadeneira, F; Uitterlinden, Ag; Imboden, M; von Eckardstein, A; Cucca, F; Nagaraja, R; Piras, Mg; Nauck, M; Schurmann, C; Budde, K; Ernst, F; Farrington, Sm; Theodoratou, E; Prokopenko, I; Stumvoll, M; Jula, A; Perola, M; Salomaa, V; Shin, Sy; Spector, Td; Sala, C; Ridker, Pm; Kähönen, M; Viikari, J; Hengstenberg, C; Nelson, Cp; Cardiogram, Consortium; Diagram, Consortium; Icbp, Consortium; Magic, Consortium; Meschia, Jf; Nalls, Ma; Sharma, P; Singleton, Ab; Kamatani, N; Zeller, T; Burnier, M; Attia, J; Laan, M; Klopp, N; Hillege, Hl; Kloiber, S; Choi, H; Pirastu, M; Tore, S; Probst Hensch, Nm; Völzke, H; Gudnason, V; Parsa, A; Schmidt, R; Whitfield, Jb; Fornage, M; Gasparini, P; Siscovick, Ds; Polašek, O; Campbell, H; Rudan, I; Bouatia Naji, N; Metspalu, A; Loos, Rj; van Duijn, Cm; Borecki, Ib; Ferrucci, L; Gambaro, G; Deary, Ij; Wolffenbuttel, Bh; Chambers, Jc; März, W; Pramstaller, Pp; Snieder, H; Gyllensten, U; Wright, Af; Navis, G; Watkins, H; Witteman, Jc; Sanna, S; Schipf, S; Dunlop, Mg; Tönjes, A; Ripatti, S; Soranzo, N; Toniolo, D; Chasman, Di; Raitakari, O; Kao, Wh; Ciullo, M; Fox, Cs; Caulfield, M; Bochud, M; Gieger, C.

Title:

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Year:

2013

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Nature Genetics

ISSN of journal:

1061-4036

N° Volume:

45

Number or Folder:

2

Page numbers:

145-154

Keyword:

serum urate concentrations, gout, genome-wide meta-analysis

Short description of contents:

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.

Web page:

http://dx.doi.org/10.1038/ng.2500

Product ID:

76491

Handle IRIS:

11562/526150

Deposited On:

March 8, 2013

Last Modified:

November 15, 2022

Bibliographic citation:

Köttgen, A; Albrecht, E; Teumer, A; Vitart, V; Krumsiek, J; Hundertmark, C; Pistis, G; Ruggiero, D; O'Seaghdha, Cm; Haller, T; Yang, Q; Tanaka, T; Johnson, Ad; Kutalik, Z; Smith, Av; Shi, J; Struchalin, M; Middelberg, Rp; Brown, Mj; Gaffo, Al; Pirastu, N; Li, G; Hayward, C; Zemunik, T; Huffman, J; Yengo, L; Zhao, Jh; Demirkan, A; Feitosa, Mf; Liu, X; Malerba, Giovanni; Lopez, Lm; van der Harst, P; Li, X; Kleber, Me; Hicks, Aa; Nolte, Im; Johansson, A; Murgia, F; Wild, Sh; Bakker, Sj; Peden, Jf; Dehghan, A; Steri, M; Tenesa, A; Lagou, V; Salo, P; Mangino, M; Rose, Lm; Lehtimäki, T; Woodward, Om; Okada, Y; Tin, A; Müller, C; Oldmeadow, C; Putku, M; Czamara, D; Kraft, P; Frogheri, L; Thun, Ga; Grotevendt, A; Gislason, Gk; Harris, Tb; Launer, Lj; Mcardle, P; Shuldiner, Ar; Boerwinkle, E; Coresh, J; Schmidt, H; Schallert, M; Martin, Ng; Montgomery, Gw; Kubo, M; Nakamura, Y; Tanaka, T; Munroe, Pb; Samani, Nj; Jacobs DR, Jr; Liu, K; D'Adamo, P; Ulivi, S; Rotter, Ji; Psaty, Bm; Vollenweider, P; Waeber, G; Campbell, S; Devuyst, O; Navarro, P; Kolcic, I; Hastie, N; Balkau, B; Froguel, P; Esko, T; Salumets, A; Khaw, Kt; Langenberg, C; Wareham, Nj; Isaacs, A; Kraja, A; Zhang, Q; Wild, Ps; Scott, Rj; Holliday, Eg; Org, E; Viigimaa, M; Bandinelli, S; Metter, Je; Lupo, Antonio; Trabetti, Elisabetta; Sorice, R; Döring, A; Lattka, E; Strauch, K; Theis, F; Waldenberger, M; Wichmann, He; Davies, G; Gow, Aj; Bruinenberg, M; LifeLines Cohort, Study; Stolk, Rp; Kooner, Js; Zhang, W; Winkelmann, Br; Boehm, Bo; Lucae, S; Penninx, Bw; Smit, Jh; Curhan, G; Mudgal, P; Plenge, Rm; Portas, L; Persico, I; Kirin, M; Wilson, Jf; Mateo Leach, I; van Gilst, Wh; Goel, A; Ongen, H; Hofman, A; Rivadeneira, F; Uitterlinden, Ag; Imboden, M; von Eckardstein, A; Cucca, F; Nagaraja, R; Piras, Mg; Nauck, M; Schurmann, C; Budde, K; Ernst, F; Farrington, Sm; Theodoratou, E; Prokopenko, I; Stumvoll, M; Jula, A; Perola, M; Salomaa, V; Shin, Sy; Spector, Td; Sala, C; Ridker, Pm; Kähönen, M; Viikari, J; Hengstenberg, C; Nelson, Cp; Cardiogram, Consortium; Diagram, Consortium; Icbp, Consortium; Magic, Consortium; Meschia, Jf; Nalls, Ma; Sharma, P; Singleton, Ab; Kamatani, N; Zeller, T; Burnier, M; Attia, J; Laan, M; Klopp, N; Hillege, Hl; Kloiber, S; Choi, H; Pirastu, M; Tore, S; Probst Hensch, Nm; Völzke, H; Gudnason, V; Parsa, A; Schmidt, R; Whitfield, Jb; Fornage, M; Gasparini, P; Siscovick, Ds; Polašek, O; Campbell, H; Rudan, I; Bouatia Naji, N; Metspalu, A; Loos, Rj; van Duijn, Cm; Borecki, Ib; Ferrucci, L; Gambaro, G; Deary, Ij; Wolffenbuttel, Bh; Chambers, Jc; März, W; Pramstaller, Pp; Snieder, H; Gyllensten, U; Wright, Af; Navis, G; Watkins, H; Witteman, Jc; Sanna, S; Schipf, S; Dunlop, Mg; Tönjes, A; Ripatti, S; Soranzo, N; Toniolo, D; Chasman, Di; Raitakari, O; Kao, Wh; Ciullo, M; Fox, Cs; Caulfield, M; Bochud, M; Gieger, C., Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. «Nature Genetics» , vol. 45 , n. 2 , 2013 , pp. 145-154

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