Pubblicazioni

Autori:

Köttgen, A; Albrecht, E; Teumer, A; Vitart, V; Krumsiek, J; Hundertmark, C; Pistis, G; Ruggiero, D; O'Seaghdha, Cm; Haller, T; Yang, Q; Tanaka, T; Johnson, Ad; Kutalik, Z; Smith, Av; Shi, J; Struchalin, M; Middelberg, Rp; Brown, Mj; Gaffo, Al; Pirastu, N; Li, G; Hayward, C; Zemunik, T; Huffman, J; Yengo, L; Zhao, Jh; Demirkan, A; Feitosa, Mf; Liu, X; Malerba, Giovanni; Lopez, Lm; van der Harst, P; Li, X; Kleber, Me; Hicks, Aa; Nolte, Im; Johansson, A; Murgia, F; Wild, Sh; Bakker, Sj; Peden, Jf; Dehghan, A; Steri, M; Tenesa, A; Lagou, V; Salo, P; Mangino, M; Rose, Lm; Lehtimäki, T; Woodward, Om; Okada, Y; Tin, A; Müller, C; Oldmeadow, C; Putku, M; Czamara, D; Kraft, P; Frogheri, L; Thun, Ga; Grotevendt, A; Gislason, Gk; Harris, Tb; Launer, Lj; Mcardle, P; Shuldiner, Ar; Boerwinkle, E; Coresh, J; Schmidt, H; Schallert, M; Martin, Ng; Montgomery, Gw; Kubo, M; Nakamura, Y; Tanaka, T; Munroe, Pb; Samani, Nj; Jacobs DR, Jr; Liu, K; D'Adamo, P; Ulivi, S; Rotter, Ji; Psaty, Bm; Vollenweider, P; Waeber, G; Campbell, S; Devuyst, O; Navarro, P; Kolcic, I; Hastie, N; Balkau, B; Froguel, P; Esko, T; Salumets, A; Khaw, Kt; Langenberg, C; Wareham, Nj; Isaacs, A; Kraja, A; Zhang, Q; Wild, Ps; Scott, Rj; Holliday, Eg; Org, E; Viigimaa, M; Bandinelli, S; Metter, Je; Lupo, Antonio; Trabetti, Elisabetta; Sorice, R; Döring, A; Lattka, E; Strauch, K; Theis, F; Waldenberger, M; Wichmann, He; Davies, G; Gow, Aj; Bruinenberg, M; LifeLines Cohort, Study; Stolk, Rp; Kooner, Js; Zhang, W; Winkelmann, Br; Boehm, Bo; Lucae, S; Penninx, Bw; Smit, Jh; Curhan, G; Mudgal, P; Plenge, Rm; Portas, L; Persico, I; Kirin, M; Wilson, Jf; Mateo Leach, I; van Gilst, Wh; Goel, A; Ongen, H; Hofman, A; Rivadeneira, F; Uitterlinden, Ag; Imboden, M; von Eckardstein, A; Cucca, F; Nagaraja, R; Piras, Mg; Nauck, M; Schurmann, C; Budde, K; Ernst, F; Farrington, Sm; Theodoratou, E; Prokopenko, I; Stumvoll, M; Jula, A; Perola, M; Salomaa, V; Shin, Sy; Spector, Td; Sala, C; Ridker, Pm; Kähönen, M; Viikari, J; Hengstenberg, C; Nelson, Cp; Cardiogram, Consortium; Diagram, Consortium; Icbp, Consortium; Magic, Consortium; Meschia, Jf; Nalls, Ma; Sharma, P; Singleton, Ab; Kamatani, N; Zeller, T; Burnier, M; Attia, J; Laan, M; Klopp, N; Hillege, Hl; Kloiber, S; Choi, H; Pirastu, M; Tore, S; Probst Hensch, Nm; Völzke, H; Gudnason, V; Parsa, A; Schmidt, R; Whitfield, Jb; Fornage, M; Gasparini, P; Siscovick, Ds; Polašek, O; Campbell, H; Rudan, I; Bouatia Naji, N; Metspalu, A; Loos, Rj; van Duijn, Cm; Borecki, Ib; Ferrucci, L; Gambaro, G; Deary, Ij; Wolffenbuttel, Bh; Chambers, Jc; März, W; Pramstaller, Pp; Snieder, H; Gyllensten, U; Wright, Af; Navis, G; Watkins, H; Witteman, Jc; Sanna, S; Schipf, S; Dunlop, Mg; Tönjes, A; Ripatti, S; Soranzo, N; Toniolo, D; Chasman, Di; Raitakari, O; Kao, Wh; Ciullo, M; Fox, Cs; Caulfield, M; Bochud, M; Gieger, C.

Titolo:

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

Anno:

2013

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Nature Genetics

ISSN Rivista:

1061-4036

N° Volume:

45

Numero o Fascicolo:

2

Intervallo pagine:

145-154

Parole chiave:

serum urate concentrations, gout, genome-wide meta-analysis

Breve descrizione dei contenuti:

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.

Pagina Web:

http://dx.doi.org/10.1038/ng.2500

Id prodotto:

76491

Handle IRIS:

11562/526150

depositato il:

8 marzo 2013

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Köttgen, A; Albrecht, E; Teumer, A; Vitart, V; Krumsiek, J; Hundertmark, C; Pistis, G; Ruggiero, D; O'Seaghdha, Cm; Haller, T; Yang, Q; Tanaka, T; Johnson, Ad; Kutalik, Z; Smith, Av; Shi, J; Struchalin, M; Middelberg, Rp; Brown, Mj; Gaffo, Al; Pirastu, N; Li, G; Hayward, C; Zemunik, T; Huffman, J; Yengo, L; Zhao, Jh; Demirkan, A; Feitosa, Mf; Liu, X; Malerba, Giovanni; Lopez, Lm; van der Harst, P; Li, X; Kleber, Me; Hicks, Aa; Nolte, Im; Johansson, A; Murgia, F; Wild, Sh; Bakker, Sj; Peden, Jf; Dehghan, A; Steri, M; Tenesa, A; Lagou, V; Salo, P; Mangino, M; Rose, Lm; Lehtimäki, T; Woodward, Om; Okada, Y; Tin, A; Müller, C; Oldmeadow, C; Putku, M; Czamara, D; Kraft, P; Frogheri, L; Thun, Ga; Grotevendt, A; Gislason, Gk; Harris, Tb; Launer, Lj; Mcardle, P; Shuldiner, Ar; Boerwinkle, E; Coresh, J; Schmidt, H; Schallert, M; Martin, Ng; Montgomery, Gw; Kubo, M; Nakamura, Y; Tanaka, T; Munroe, Pb; Samani, Nj; Jacobs DR, Jr; Liu, K; D'Adamo, P; Ulivi, S; Rotter, Ji; Psaty, Bm; Vollenweider, P; Waeber, G; Campbell, S; Devuyst, O; Navarro, P; Kolcic, I; Hastie, N; Balkau, B; Froguel, P; Esko, T; Salumets, A; Khaw, Kt; Langenberg, C; Wareham, Nj; Isaacs, A; Kraja, A; Zhang, Q; Wild, Ps; Scott, Rj; Holliday, Eg; Org, E; Viigimaa, M; Bandinelli, S; Metter, Je; Lupo, Antonio; Trabetti, Elisabetta; Sorice, R; Döring, A; Lattka, E; Strauch, K; Theis, F; Waldenberger, M; Wichmann, He; Davies, G; Gow, Aj; Bruinenberg, M; LifeLines Cohort, Study; Stolk, Rp; Kooner, Js; Zhang, W; Winkelmann, Br; Boehm, Bo; Lucae, S; Penninx, Bw; Smit, Jh; Curhan, G; Mudgal, P; Plenge, Rm; Portas, L; Persico, I; Kirin, M; Wilson, Jf; Mateo Leach, I; van Gilst, Wh; Goel, A; Ongen, H; Hofman, A; Rivadeneira, F; Uitterlinden, Ag; Imboden, M; von Eckardstein, A; Cucca, F; Nagaraja, R; Piras, Mg; Nauck, M; Schurmann, C; Budde, K; Ernst, F; Farrington, Sm; Theodoratou, E; Prokopenko, I; Stumvoll, M; Jula, A; Perola, M; Salomaa, V; Shin, Sy; Spector, Td; Sala, C; Ridker, Pm; Kähönen, M; Viikari, J; Hengstenberg, C; Nelson, Cp; Cardiogram, Consortium; Diagram, Consortium; Icbp, Consortium; Magic, Consortium; Meschia, Jf; Nalls, Ma; Sharma, P; Singleton, Ab; Kamatani, N; Zeller, T; Burnier, M; Attia, J; Laan, M; Klopp, N; Hillege, Hl; Kloiber, S; Choi, H; Pirastu, M; Tore, S; Probst Hensch, Nm; Völzke, H; Gudnason, V; Parsa, A; Schmidt, R; Whitfield, Jb; Fornage, M; Gasparini, P; Siscovick, Ds; Polašek, O; Campbell, H; Rudan, I; Bouatia Naji, N; Metspalu, A; Loos, Rj; van Duijn, Cm; Borecki, Ib; Ferrucci, L; Gambaro, G; Deary, Ij; Wolffenbuttel, Bh; Chambers, Jc; März, W; Pramstaller, Pp; Snieder, H; Gyllensten, U; Wright, Af; Navis, G; Watkins, H; Witteman, Jc; Sanna, S; Schipf, S; Dunlop, Mg; Tönjes, A; Ripatti, S; Soranzo, N; Toniolo, D; Chasman, Di; Raitakari, O; Kao, Wh; Ciullo, M; Fox, Cs; Caulfield, M; Bochud, M; Gieger, C., Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. «Nature Genetics» , vol. 45 , n. 2 , 2013 , pp. 145-154

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