Pubblicazioni

Autori:

Stefani, A.; Riello, Marianna; Rossini, Fabio; Mariotto, Sara; Fenzi, Flavio; Gambina, G.; Zanusso, Gianluigi; Monaco, Salvatore

Titolo:

Neurosyphilis manifesting with rapidly progressive dementia: report of three cases.

Anno:

2013

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

NEUROLOGICAL SCIENCES

ISSN Rivista:

1590-1874

N° Volume:

34

Numero o Fascicolo:

11

Intervallo pagine:

2027-2030

Parole chiave:

general paresis; neurosyphilis; rapidly progressive dementia

Breve descrizione dei contenuti:

Neurosyphilis is rather an unusual cause of dementia characterized by a rapidly progressive course and psychiatric symptoms. Diagnosis of neurosyphilis should be suspected in the presence of a global cognitive impairment consisting in disorientation, amnesia and severe impairment of speech and judgement and psychiatric symptoms such as depression, mania and psychosis, with a subacute onset. More commonly, clinical manifestations of neurosyphilis include general PARESIS (involvement of Personality, Affect, Reflexes, Eye, Sensorium, Intellect and Speech). Upon clinical suspicion, diagnosis of neurosyphilis is confirmed by a reactive cerebrospinal fluid (CSF)-Venereal Disease Research Laboratory. Here we report three Human Immunodeficiency Virus (HIV)-negative male patients presenting with psychiatric symptoms and a rapidly evolving dementia. Although magnetic resonance imaging did not address to diagnosis, CSF examination was mandatory in neurosyphilis diagnosis. Other diagnostic tools such as neuropsychology and single-photon emission computed tomography resulted supportive in the diagnosis. We showed that a prompt antibiotic treatment might stop disease progression. Therefore, neurosyphilis should be always considered even in HIV-negative patients in the presence of unexpected psychiatric symptoms accompanied by a rapidly evolving cognitive decline.

Id prodotto:

78674

Handle IRIS:

11562/619360

depositato il:

21 novembre 2013

ultima modifica:

13 novembre 2022

Citazione bibliografica:

Stefani, A.; Riello, Marianna; Rossini, Fabio; Mariotto, Sara; Fenzi, Flavio; Gambina, G.; Zanusso, Gianluigi; Monaco, Salvatore, Neurosyphilis manifesting with rapidly progressive dementia: report of three cases. «NEUROLOGICAL SCIENCES» , vol. 34 , n. 11 , 2013 , pp. 2027-2030

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