Publications

Authors:

Bertini, Giuseppe; Bramanti, P.; Constantin, Gabriela; Pellitteri, Michele; Radu, Beatrice Mihaela; Radu, Mihai; Fabene, Paolo

Title:

New players in the neurovascular unit: Insights from experimental and clinical epilepsy.

Year:

2013

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Neurochemistry International

ISSN of journal:

0197-0186

N° Volume:

63

Number or Folder:

7

Page numbers:

652-659

Keyword:

blood-brain barrier; epilepsy; glial cells; neurons; neurovascular unit; seizures

Short description of contents:

The conventional notion that neurons are exclusively responsible for brain signaling is increasingly challenged by the idea that brain function in fact depends on a complex interplay between neurons, glial cells, vascular endothelium, and immune-related blood cells. Recent data demonstrates that neuronal activity is profoundly affected by an entire cellular and extracellular 'orchestra', the so-called neurovascular unit (NVU). Among the 'musical instruments' of this orchestra, there may be molecules long-known in biomedicine as important mediators of inflammatory and immune responses in the organism, as well as non-neuronal cells, e.g., leukocytes. We here review recent evidence on the structure and function of the NVU, both in the healthy brain and in pathological conditions, such as the abnormal NVU activation observed in epilepsy. We will argue that a better understanding of NVU function will require the addition of new players to the 'orchestra'.

Web page:

http://dx.doi.org/10.1016/j.neuint.2013.08.001

Product ID:

78863

Handle IRIS:

11562/645351

Deposited On:

December 12, 2013

Last Modified:

November 16, 2022

Bibliographic citation:

Bertini, Giuseppe; Bramanti, P.; Constantin, Gabriela; Pellitteri, Michele; Radu, Beatrice Mihaela; Radu, Mihai; Fabene, Paolo, New players in the neurovascular unit: Insights from experimental and clinical epilepsy. «Neurochemistry International» , vol. 63 , n. 7 , 2013 , pp. 652-659

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo