Publications

Authors:

Mariotto, Sara; Ferrari, Sergio; Monaco, Salvatore

Title:

HCV-related central and peripheral nervous system demyelinating disorders.

Year:

2014

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

INFLAMMATION & ALLERGY - DRUG TARGETS

ISSN of journal:

1871-5281

N° Volume:

13

Number or Folder:

5

Page numbers:

299-304

Keyword:

anti-aquaporin-4; anti-MAG neuropathy; demyelination; HCV; neuromyelitis optica; transverse myelitis

Short description of contents:

Chronic infection with hepatitis C virus (HCV) is associated with a large spectrum of extrahepatic manifestations (EHMs), mostly immunologic/rheumatologic in nature owing to B-cell proliferation and clonal expansion. Neurological complications are thought to be immune-mediated or secondary to invasion of neural tissues by HCV, as postulated in transverse myelitis and encephalopathic forms. Primarily axonal neuropathies, including sensorimotor polyneuropathy, large or small fiber sensory neuropathy, motor polyneuropathy, mononeuritis, mononeuritis multiplex, or overlapping syndrome, represent the most common neurological complications of chronic HCV infection. In addition, a number of peripheral demyelinating disorders are encountered, such as chronic inflammatory demyelinating polyneuropathy, the Lewis-Sumner syndrome, and cryoglobulin-associated polyneuropathy with demyelinating features. The spectrum of demyelinating forms also includes rare cases of iatrogenic central and peripheral nervous system disorders, occurring during treatment with pegylated interferon. Herein, we review HCV-related demyelinating conditions, and disclose the novel observation on the significantly increased frequency of chronic demyelinating neuropathy with anti-myelin-associated glycoprotein antibodies in a cohort of 59 consecutive patients recruited at our institution. We also report a second case of neuromyelitis optica with serum IgG autoantibody against the water channel aquaporin-4. The prompt recognition of these atypical and underestimated complications of HCV infection is of crucial importance in deciding which treatment option a patient should be offered. - See more at: http://www.eurekaselect.com/124430/article#sthash.mt4Dr1bK.dpuf

Web page:

http://dx.doi.org/10.2174/1871528113666140908113841

Product ID:

85898

Handle IRIS:

11562/786367

Deposited On:

February 10, 2015

Last Modified:

November 1, 2022

Bibliographic citation:

Mariotto, Sara; Ferrari, Sergio; Monaco, Salvatore, HCV-related central and peripheral nervous system demyelinating disorders. «INFLAMMATION & ALLERGY - DRUG TARGETS» , vol. 13 , n. 5 , 2014 , pp. 299-304

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