Publications

Authors:

Ripke, S; Neale, Bm; Corvin, A; Walters, Jt; Farh, Kh; Holmans, Pa; Lee, P; Bulik Sullivan, B; Collier, Da; Huang, H; Pers, Th; Agartz, I; Agerbo, E; Albus, M; Alexander, M; Amin, F; Bacanu, Sa; Begemann, M; Belliveau RA, Jr; Bene, J; Bergen, Se; Bevilacqua, E; Bigdeli, Tb; Black, Dw; Bruggeman, R; Buccola, Ng; Buckner, Rl; Byerley, W; Cahn, W; Cai, G; Campion, D; Cantor, Rm; Carr, Vj; Carrera, N; Catts, Sv; Chambert, Kd; Chan, Rc; Chen, Ry; Chen, Ey; Cheng, W; Cheung, Ef; Chong, Sa; Cloninger, Cr; Cohen, D; Cohen, N; Cormican, P; Craddock, N; Crowley, Jj; Curtis, D; Davidson, M; Davis, Kl; Degenhardt, F; Del Favero, J; Demontis, D; Dikeos, D; Dinan, T; Djurovic, S; Donohoe, G; Drapeau, E; Duan, J; Dudbridge, F; Durmishi, N; Eichhammer, P; Eriksson, J; Escott Price, V; Essioux, L; Fanous, Ah; Farrell, Ms; Frank, J; Franke, L; Freedman, R; Freimer, Nb; Friedl, M; Friedman, Ji; Fromer, M; Genovese, G; Georgieva, L; Giegling, I; Giusti Rodríguez, P; Godard, S; Goldstein, Ji; Golimbet, V; Gopal, S; Gratten, J; de Haan, L; Hammer, C; Hamshere, Ml; Hansen, M; Hansen, T; Haroutunian, V; Hartmann, Am; Henskens, Fa; Herms, S; Hirschhorn, Jn; Hoffmann, P; Hofman, A; Hollegaard, Mv; Hougaard, Dm; Ikeda, M; Joa, I; Julià, A; Kahn, Rs; Kalaydjieva, L; Karachanak Yankova, S; Karjalainen, J; Kavanagh, D; Keller, Mc; Kennedy, Jl; Khrunin, A; Kim, Y; Klovins, J; Knowles, Ja; Konte, B; Kucinskas, V; Ausrele Kucinskiene, Z; Kuzelova Ptackova, H; Kähler, Ak; Laurent, C; Keong, Jl; Lee, Sh; Legge, Se; Lerer, B; Li, M; Li, T; Liang, Ky; Lieberman, J; Limborska, S; Loughland, Cm; Lubinski, J; Lönnqvist, J; Macek M., Jr; Magnusson, Pk; Maher, Bs; Maier, W; Mallet, J; Marsal, S; Mattheisen, M; Mattingsdal, M; Mccarley, Rw; Mcdonald, C; Mcintosh, Am; Meier, S; Meijer, Cj; Melegh, B; Melle, I; Mesholam Gately, Ri; Metspalu, A; Michie, Pt; Milani, L; Milanova, V; Mokrab, Y; Morris, Dw; Mors, O; Murphy, Kc; Murray, Rm; Myin Germeys, I; Müller Myhsok, B; Nelis, M; Nenadic, I; Nertney, Da; Nestadt, G; Nicodemus, Kk; Nikitina Zake, L; Nisenbaum, L; Nordin, A; O'Callaghan, E; O'Dushlaine, C; O'Neill, Fa; Oh, Sy; Olincy, A; Olsen, L; Van Os, J; Pantelis, C; Papadimitriou, Gn; Papiol, S; Parkhomenko, E; Pato, Mt; Paunio, T; Pejovic Milovancevic, M; Perkins, Do; Pietiläinen, O; Pimm, J; Pocklington, Aj; Powell, J; Price, A; Pulver, Ae; Purcell, Sm; Quested, D; Rasmussen, Hb; Reichenberg, A; Reimers, Ma; Richards, Al; Roffman, Jl; Roussos, P; Ruderfer, Dm; Salomaa, V; Sanders, Ar; Schall, U; Schubert, Cr; Schulze, Tg; Schwab, Sg; Scolnick, Em; Scott, Rj; Seidman, Lj; Shi, J; Sigurdsson, E; Silagadze, T; Silverman, Jm; Sim, K; Slominsky, P; Smoller, Jw; So, Hc; Spencer, Ca; Stahl, Ea; Stefansson, H; Steinberg, S; Stogmann, E; Straub, Re; Strengman, E; Strohmaier, J; Stroup, Ts; Subramaniam, M; Suvisaari, J; Svrakic, Dm; Szatkiewicz, Jp; Söderman, E; Thirumalai, S; Toncheva, D; Tosato, Sarah; Veijola, J; Waddington, J; Walsh, D; Wang, D; Wang, Q; Webb, Bt; Weiser, M; Wildenauer, Db; Williams, Nm; Williams, S; Witt, Sh; Wolen, Ar; Wong, Eh; Wormley, Bk; Xi, Hs; Zai, Cc; Zheng, X; Zimprich, F; Wray, Nr; Stefansson, K; Visscher, Pm; Adolfsson, R; Andreassen, Oa; Blackwood, Dh; Bramon, E; Buxbaum, Jd; Børglum, Ad; Cichon, S; Darvasi, A; Domenici, E; Ehrenreich, H; Esko, T; Gejman, Pv; Gill, M; Gurling, H; Hultman, Cm; Iwata, N; Jablensky, Av; Jönsson, Eg; Kendler, Ks; Kirov, G; Knight, J; Lencz, T; Levinson, Df; Li, Qs; Liu, J; Malhotra, Ak; Mccarroll, Sa; Mcquillin, A; Moran, Jl; Mortensen, Pb; Mowry, Bj; Nöthen, Mm; Ophoff, Ra; Owen, Mj; Palotie, A; Pato, Cn; Petryshen, Tl; Posthuma, D; Rietschel, M; Riley, Bp; Rujescu, D; Sham, Pc; Sklar, P; St Clair, D; Weinberger, Dr; Wendland, Jr; Werge, T; Daly, Mj; Sullivan, Pf; O'Donovan, M. C.

Title:

Biological insights from 108 schizophrenia-associated genetic loci

Year:

2014

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Nature

ISSN of journal:

0028-0836

N° Volume:

511

Number or Folder:

7510

Page numbers:

421-427

Keyword:

schizophrenia; Genome-Wide Association Study; Glutamatergic system

Short description of contents:

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

Web page:

https://doi.org/10.1038/nature13595

Product ID:

84248

Handle IRIS:

11562/867773

Deposited On:

January 8, 2015

Last Modified:

November 3, 2022

Bibliographic citation:

Ripke, S; Neale, Bm; Corvin, A; Walters, Jt; Farh, Kh; Holmans, Pa; Lee, P; Bulik Sullivan, B; Collier, Da; Huang, H; Pers, Th; Agartz, I; Agerbo, E; Albus, M; Alexander, M; Amin, F; Bacanu, Sa; Begemann, M; Belliveau RA, Jr; Bene, J; Bergen, Se; Bevilacqua, E; Bigdeli, Tb; Black, Dw; Bruggeman, R; Buccola, Ng; Buckner, Rl; Byerley, W; Cahn, W; Cai, G; Campion, D; Cantor, Rm; Carr, Vj; Carrera, N; Catts, Sv; Chambert, Kd; Chan, Rc; Chen, Ry; Chen, Ey; Cheng, W; Cheung, Ef; Chong, Sa; Cloninger, Cr; Cohen, D; Cohen, N; Cormican, P; Craddock, N; Crowley, Jj; Curtis, D; Davidson, M; Davis, Kl; Degenhardt, F; Del Favero, J; Demontis, D; Dikeos, D; Dinan, T; Djurovic, S; Donohoe, G; Drapeau, E; Duan, J; Dudbridge, F; Durmishi, N; Eichhammer, P; Eriksson, J; Escott Price, V; Essioux, L; Fanous, Ah; Farrell, Ms; Frank, J; Franke, L; Freedman, R; Freimer, Nb; Friedl, M; Friedman, Ji; Fromer, M; Genovese, G; Georgieva, L; Giegling, I; Giusti Rodríguez, P; Godard, S; Goldstein, Ji; Golimbet, V; Gopal, S; Gratten, J; de Haan, L; Hammer, C; Hamshere, Ml; Hansen, M; Hansen, T; Haroutunian, V; Hartmann, Am; Henskens, Fa; Herms, S; Hirschhorn, Jn; Hoffmann, P; Hofman, A; Hollegaard, Mv; Hougaard, Dm; Ikeda, M; Joa, I; Julià, A; Kahn, Rs; Kalaydjieva, L; Karachanak Yankova, S; Karjalainen, J; Kavanagh, D; Keller, Mc; Kennedy, Jl; Khrunin, A; Kim, Y; Klovins, J; Knowles, Ja; Konte, B; Kucinskas, V; Ausrele Kucinskiene, Z; Kuzelova Ptackova, H; Kähler, Ak; Laurent, C; Keong, Jl; Lee, Sh; Legge, Se; Lerer, B; Li, M; Li, T; Liang, Ky; Lieberman, J; Limborska, S; Loughland, Cm; Lubinski, J; Lönnqvist, J; Macek M., Jr; Magnusson, Pk; Maher, Bs; Maier, W; Mallet, J; Marsal, S; Mattheisen, M; Mattingsdal, M; Mccarley, Rw; Mcdonald, C; Mcintosh, Am; Meier, S; Meijer, Cj; Melegh, B; Melle, I; Mesholam Gately, Ri; Metspalu, A; Michie, Pt; Milani, L; Milanova, V; Mokrab, Y; Morris, Dw; Mors, O; Murphy, Kc; Murray, Rm; Myin Germeys, I; Müller Myhsok, B; Nelis, M; Nenadic, I; Nertney, Da; Nestadt, G; Nicodemus, Kk; Nikitina Zake, L; Nisenbaum, L; Nordin, A; O'Callaghan, E; O'Dushlaine, C; O'Neill, Fa; Oh, Sy; Olincy, A; Olsen, L; Van Os, J; Pantelis, C; Papadimitriou, Gn; Papiol, S; Parkhomenko, E; Pato, Mt; Paunio, T; Pejovic Milovancevic, M; Perkins, Do; Pietiläinen, O; Pimm, J; Pocklington, Aj; Powell, J; Price, A; Pulver, Ae; Purcell, Sm; Quested, D; Rasmussen, Hb; Reichenberg, A; Reimers, Ma; Richards, Al; Roffman, Jl; Roussos, P; Ruderfer, Dm; Salomaa, V; Sanders, Ar; Schall, U; Schubert, Cr; Schulze, Tg; Schwab, Sg; Scolnick, Em; Scott, Rj; Seidman, Lj; Shi, J; Sigurdsson, E; Silagadze, T; Silverman, Jm; Sim, K; Slominsky, P; Smoller, Jw; So, Hc; Spencer, Ca; Stahl, Ea; Stefansson, H; Steinberg, S; Stogmann, E; Straub, Re; Strengman, E; Strohmaier, J; Stroup, Ts; Subramaniam, M; Suvisaari, J; Svrakic, Dm; Szatkiewicz, Jp; Söderman, E; Thirumalai, S; Toncheva, D; Tosato, Sarah; Veijola, J; Waddington, J; Walsh, D; Wang, D; Wang, Q; Webb, Bt; Weiser, M; Wildenauer, Db; Williams, Nm; Williams, S; Witt, Sh; Wolen, Ar; Wong, Eh; Wormley, Bk; Xi, Hs; Zai, Cc; Zheng, X; Zimprich, F; Wray, Nr; Stefansson, K; Visscher, Pm; Adolfsson, R; Andreassen, Oa; Blackwood, Dh; Bramon, E; Buxbaum, Jd; Børglum, Ad; Cichon, S; Darvasi, A; Domenici, E; Ehrenreich, H; Esko, T; Gejman, Pv; Gill, M; Gurling, H; Hultman, Cm; Iwata, N; Jablensky, Av; Jönsson, Eg; Kendler, Ks; Kirov, G; Knight, J; Lencz, T; Levinson, Df; Li, Qs; Liu, J; Malhotra, Ak; Mccarroll, Sa; Mcquillin, A; Moran, Jl; Mortensen, Pb; Mowry, Bj; Nöthen, Mm; Ophoff, Ra; Owen, Mj; Palotie, A; Pato, Cn; Petryshen, Tl; Posthuma, D; Rietschel, M; Riley, Bp; Rujescu, D; Sham, Pc; Sklar, P; St Clair, D; Weinberger, Dr; Wendland, Jr; Werge, T; Daly, Mj; Sullivan, Pf; O'Donovan, M. C., Biological insights from 108 schizophrenia-associated genetic loci «Nature» , vol. 511 , n. 7510 , 2014 , pp. 421-427

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