Pubblicazioni

Autori:

Ripke, S; Neale, Bm; Corvin, A; Walters, Jt; Farh, Kh; Holmans, Pa; Lee, P; Bulik Sullivan, B; Collier, Da; Huang, H; Pers, Th; Agartz, I; Agerbo, E; Albus, M; Alexander, M; Amin, F; Bacanu, Sa; Begemann, M; Belliveau RA, Jr; Bene, J; Bergen, Se; Bevilacqua, E; Bigdeli, Tb; Black, Dw; Bruggeman, R; Buccola, Ng; Buckner, Rl; Byerley, W; Cahn, W; Cai, G; Campion, D; Cantor, Rm; Carr, Vj; Carrera, N; Catts, Sv; Chambert, Kd; Chan, Rc; Chen, Ry; Chen, Ey; Cheng, W; Cheung, Ef; Chong, Sa; Cloninger, Cr; Cohen, D; Cohen, N; Cormican, P; Craddock, N; Crowley, Jj; Curtis, D; Davidson, M; Davis, Kl; Degenhardt, F; Del Favero, J; Demontis, D; Dikeos, D; Dinan, T; Djurovic, S; Donohoe, G; Drapeau, E; Duan, J; Dudbridge, F; Durmishi, N; Eichhammer, P; Eriksson, J; Escott Price, V; Essioux, L; Fanous, Ah; Farrell, Ms; Frank, J; Franke, L; Freedman, R; Freimer, Nb; Friedl, M; Friedman, Ji; Fromer, M; Genovese, G; Georgieva, L; Giegling, I; Giusti Rodríguez, P; Godard, S; Goldstein, Ji; Golimbet, V; Gopal, S; Gratten, J; de Haan, L; Hammer, C; Hamshere, Ml; Hansen, M; Hansen, T; Haroutunian, V; Hartmann, Am; Henskens, Fa; Herms, S; Hirschhorn, Jn; Hoffmann, P; Hofman, A; Hollegaard, Mv; Hougaard, Dm; Ikeda, M; Joa, I; Julià, A; Kahn, Rs; Kalaydjieva, L; Karachanak Yankova, S; Karjalainen, J; Kavanagh, D; Keller, Mc; Kennedy, Jl; Khrunin, A; Kim, Y; Klovins, J; Knowles, Ja; Konte, B; Kucinskas, V; Ausrele Kucinskiene, Z; Kuzelova Ptackova, H; Kähler, Ak; Laurent, C; Keong, Jl; Lee, Sh; Legge, Se; Lerer, B; Li, M; Li, T; Liang, Ky; Lieberman, J; Limborska, S; Loughland, Cm; Lubinski, J; Lönnqvist, J; Macek M., Jr; Magnusson, Pk; Maher, Bs; Maier, W; Mallet, J; Marsal, S; Mattheisen, M; Mattingsdal, M; Mccarley, Rw; Mcdonald, C; Mcintosh, Am; Meier, S; Meijer, Cj; Melegh, B; Melle, I; Mesholam Gately, Ri; Metspalu, A; Michie, Pt; Milani, L; Milanova, V; Mokrab, Y; Morris, Dw; Mors, O; Murphy, Kc; Murray, Rm; Myin Germeys, I; Müller Myhsok, B; Nelis, M; Nenadic, I; Nertney, Da; Nestadt, G; Nicodemus, Kk; Nikitina Zake, L; Nisenbaum, L; Nordin, A; O'Callaghan, E; O'Dushlaine, C; O'Neill, Fa; Oh, Sy; Olincy, A; Olsen, L; Van Os, J; Pantelis, C; Papadimitriou, Gn; Papiol, S; Parkhomenko, E; Pato, Mt; Paunio, T; Pejovic Milovancevic, M; Perkins, Do; Pietiläinen, O; Pimm, J; Pocklington, Aj; Powell, J; Price, A; Pulver, Ae; Purcell, Sm; Quested, D; Rasmussen, Hb; Reichenberg, A; Reimers, Ma; Richards, Al; Roffman, Jl; Roussos, P; Ruderfer, Dm; Salomaa, V; Sanders, Ar; Schall, U; Schubert, Cr; Schulze, Tg; Schwab, Sg; Scolnick, Em; Scott, Rj; Seidman, Lj; Shi, J; Sigurdsson, E; Silagadze, T; Silverman, Jm; Sim, K; Slominsky, P; Smoller, Jw; So, Hc; Spencer, Ca; Stahl, Ea; Stefansson, H; Steinberg, S; Stogmann, E; Straub, Re; Strengman, E; Strohmaier, J; Stroup, Ts; Subramaniam, M; Suvisaari, J; Svrakic, Dm; Szatkiewicz, Jp; Söderman, E; Thirumalai, S; Toncheva, D; Tosato, Sarah; Veijola, J; Waddington, J; Walsh, D; Wang, D; Wang, Q; Webb, Bt; Weiser, M; Wildenauer, Db; Williams, Nm; Williams, S; Witt, Sh; Wolen, Ar; Wong, Eh; Wormley, Bk; Xi, Hs; Zai, Cc; Zheng, X; Zimprich, F; Wray, Nr; Stefansson, K; Visscher, Pm; Adolfsson, R; Andreassen, Oa; Blackwood, Dh; Bramon, E; Buxbaum, Jd; Børglum, Ad; Cichon, S; Darvasi, A; Domenici, E; Ehrenreich, H; Esko, T; Gejman, Pv; Gill, M; Gurling, H; Hultman, Cm; Iwata, N; Jablensky, Av; Jönsson, Eg; Kendler, Ks; Kirov, G; Knight, J; Lencz, T; Levinson, Df; Li, Qs; Liu, J; Malhotra, Ak; Mccarroll, Sa; Mcquillin, A; Moran, Jl; Mortensen, Pb; Mowry, Bj; Nöthen, Mm; Ophoff, Ra; Owen, Mj; Palotie, A; Pato, Cn; Petryshen, Tl; Posthuma, D; Rietschel, M; Riley, Bp; Rujescu, D; Sham, Pc; Sklar, P; St Clair, D; Weinberger, Dr; Wendland, Jr; Werge, T; Daly, Mj; Sullivan, Pf; O'Donovan, M. C.

Titolo:

Biological insights from 108 schizophrenia-associated genetic loci

Anno:

2014

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

Nature

ISSN Rivista:

0028-0836

N° Volume:

511

Numero o Fascicolo:

7510

Intervallo pagine:

421-427

Parole chiave:

schizophrenia; Genome-Wide Association Study; Glutamatergic system

Breve descrizione dei contenuti:

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

Pagina Web:

https://doi.org/10.1038/nature13595

Id prodotto:

84248

Handle IRIS:

11562/867773

depositato il:

8 gennaio 2015

ultima modifica:

3 novembre 2022

Citazione bibliografica:

Ripke, S; Neale, Bm; Corvin, A; Walters, Jt; Farh, Kh; Holmans, Pa; Lee, P; Bulik Sullivan, B; Collier, Da; Huang, H; Pers, Th; Agartz, I; Agerbo, E; Albus, M; Alexander, M; Amin, F; Bacanu, Sa; Begemann, M; Belliveau RA, Jr; Bene, J; Bergen, Se; Bevilacqua, E; Bigdeli, Tb; Black, Dw; Bruggeman, R; Buccola, Ng; Buckner, Rl; Byerley, W; Cahn, W; Cai, G; Campion, D; Cantor, Rm; Carr, Vj; Carrera, N; Catts, Sv; Chambert, Kd; Chan, Rc; Chen, Ry; Chen, Ey; Cheng, W; Cheung, Ef; Chong, Sa; Cloninger, Cr; Cohen, D; Cohen, N; Cormican, P; Craddock, N; Crowley, Jj; Curtis, D; Davidson, M; Davis, Kl; Degenhardt, F; Del Favero, J; Demontis, D; Dikeos, D; Dinan, T; Djurovic, S; Donohoe, G; Drapeau, E; Duan, J; Dudbridge, F; Durmishi, N; Eichhammer, P; Eriksson, J; Escott Price, V; Essioux, L; Fanous, Ah; Farrell, Ms; Frank, J; Franke, L; Freedman, R; Freimer, Nb; Friedl, M; Friedman, Ji; Fromer, M; Genovese, G; Georgieva, L; Giegling, I; Giusti Rodríguez, P; Godard, S; Goldstein, Ji; Golimbet, V; Gopal, S; Gratten, J; de Haan, L; Hammer, C; Hamshere, Ml; Hansen, M; Hansen, T; Haroutunian, V; Hartmann, Am; Henskens, Fa; Herms, S; Hirschhorn, Jn; Hoffmann, P; Hofman, A; Hollegaard, Mv; Hougaard, Dm; Ikeda, M; Joa, I; Julià, A; Kahn, Rs; Kalaydjieva, L; Karachanak Yankova, S; Karjalainen, J; Kavanagh, D; Keller, Mc; Kennedy, Jl; Khrunin, A; Kim, Y; Klovins, J; Knowles, Ja; Konte, B; Kucinskas, V; Ausrele Kucinskiene, Z; Kuzelova Ptackova, H; Kähler, Ak; Laurent, C; Keong, Jl; Lee, Sh; Legge, Se; Lerer, B; Li, M; Li, T; Liang, Ky; Lieberman, J; Limborska, S; Loughland, Cm; Lubinski, J; Lönnqvist, J; Macek M., Jr; Magnusson, Pk; Maher, Bs; Maier, W; Mallet, J; Marsal, S; Mattheisen, M; Mattingsdal, M; Mccarley, Rw; Mcdonald, C; Mcintosh, Am; Meier, S; Meijer, Cj; Melegh, B; Melle, I; Mesholam Gately, Ri; Metspalu, A; Michie, Pt; Milani, L; Milanova, V; Mokrab, Y; Morris, Dw; Mors, O; Murphy, Kc; Murray, Rm; Myin Germeys, I; Müller Myhsok, B; Nelis, M; Nenadic, I; Nertney, Da; Nestadt, G; Nicodemus, Kk; Nikitina Zake, L; Nisenbaum, L; Nordin, A; O'Callaghan, E; O'Dushlaine, C; O'Neill, Fa; Oh, Sy; Olincy, A; Olsen, L; Van Os, J; Pantelis, C; Papadimitriou, Gn; Papiol, S; Parkhomenko, E; Pato, Mt; Paunio, T; Pejovic Milovancevic, M; Perkins, Do; Pietiläinen, O; Pimm, J; Pocklington, Aj; Powell, J; Price, A; Pulver, Ae; Purcell, Sm; Quested, D; Rasmussen, Hb; Reichenberg, A; Reimers, Ma; Richards, Al; Roffman, Jl; Roussos, P; Ruderfer, Dm; Salomaa, V; Sanders, Ar; Schall, U; Schubert, Cr; Schulze, Tg; Schwab, Sg; Scolnick, Em; Scott, Rj; Seidman, Lj; Shi, J; Sigurdsson, E; Silagadze, T; Silverman, Jm; Sim, K; Slominsky, P; Smoller, Jw; So, Hc; Spencer, Ca; Stahl, Ea; Stefansson, H; Steinberg, S; Stogmann, E; Straub, Re; Strengman, E; Strohmaier, J; Stroup, Ts; Subramaniam, M; Suvisaari, J; Svrakic, Dm; Szatkiewicz, Jp; Söderman, E; Thirumalai, S; Toncheva, D; Tosato, Sarah; Veijola, J; Waddington, J; Walsh, D; Wang, D; Wang, Q; Webb, Bt; Weiser, M; Wildenauer, Db; Williams, Nm; Williams, S; Witt, Sh; Wolen, Ar; Wong, Eh; Wormley, Bk; Xi, Hs; Zai, Cc; Zheng, X; Zimprich, F; Wray, Nr; Stefansson, K; Visscher, Pm; Adolfsson, R; Andreassen, Oa; Blackwood, Dh; Bramon, E; Buxbaum, Jd; Børglum, Ad; Cichon, S; Darvasi, A; Domenici, E; Ehrenreich, H; Esko, T; Gejman, Pv; Gill, M; Gurling, H; Hultman, Cm; Iwata, N; Jablensky, Av; Jönsson, Eg; Kendler, Ks; Kirov, G; Knight, J; Lencz, T; Levinson, Df; Li, Qs; Liu, J; Malhotra, Ak; Mccarroll, Sa; Mcquillin, A; Moran, Jl; Mortensen, Pb; Mowry, Bj; Nöthen, Mm; Ophoff, Ra; Owen, Mj; Palotie, A; Pato, Cn; Petryshen, Tl; Posthuma, D; Rietschel, M; Riley, Bp; Rujescu, D; Sham, Pc; Sklar, P; St Clair, D; Weinberger, Dr; Wendland, Jr; Werge, T; Daly, Mj; Sullivan, Pf; O'Donovan, M. C., Biological insights from 108 schizophrenia-associated genetic loci «Nature» , vol. 511 , n. 7510 , 2014 , pp. 421-427

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