Pubblicazioni

Autori:

Ira, Elisa; Bonetto, Chiara; Zanoni, Martina; Bottacini, Alessandro; Mazzoncini, Rodolfo; Martini, Lisa; Garozzo, Angela; Lasalvia, Antonio; Tansella, Michele; Ruggeri, Mirella; Tosato, Sarah

Titolo:

Neurological soft signs and prepulse inhibition of the startle reflex in psychosis: A pilot study

Anno:

2015

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

A Stampa

Referee:

Sì

Nome rivista:

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE

ISSN Rivista:

1365-1501

N° Volume:

19

Numero o Fascicolo:

4

Intervallo pagine:

276-284

Parole chiave:

NSS; PPI; motor sequencing signs; schizophrenia; sensory integration signs

Breve descrizione dei contenuti:

OBJECTIVE: Prepulse inhibition (PPI) of the startle reflex deficit and neurological soft signs (NSS) are two markers of vulnerability to psychosis. This study investigated the possibility of a PPI-NSS relation due to a putative common biological substrate, hypothesizing that patients with higher NSS scores also show higher PPI deficits. Moreover, we examined the possibility of an association of PPI deficits and NSS with negative symptoms. METHODS: Fifteen subjects with psychosis and fifteen healthy controls underwent PPI and NSS evaluations. RESULTS: Patients did not exhibit higher PPI deficits but only higher NSS rates (p < 0.01), as compared with healthy controls. Higher NSS rates were not associated with PPI deficits, and NSS sensory integration signs correlated positively with negative symptoms (p < 0.01). CONCLUSION: Our study supported the hypothesis that NSS are trait markers whereas PPI deficits state markers and that their putative common biological substrate is not sufficient to determinate an association between them. The study hypothesis, however, needs further investigation.

Pagina Web:

https://doi.org/10.3109/13651501.2015.1016041

Id prodotto:

88880

Handle IRIS:

11562/929360

ultima modifica:

15 novembre 2022

Citazione bibliografica:

Ira, Elisa; Bonetto, Chiara; Zanoni, Martina; Bottacini, Alessandro; Mazzoncini, Rodolfo; Martini, Lisa; Garozzo, Angela; Lasalvia, Antonio; Tansella, Michele; Ruggeri, Mirella; Tosato, Sarah, Neurological soft signs and prepulse inhibition of the startle reflex in psychosis: A pilot study «INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE» , vol. 19 , n. 4 , 2015 , pp. 276-284

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