Publications

Authors:

Tosato, Sarah; Ira, Elisa; Russo, Manuela; Iyegbe, Conrad; Lasalvia, Antonio; Di Forti, Marta; Morgan, Kevin; Bonetto, Chiara; Morgan, Craig; De Rossi, Moreno; Nicolau, Stylianos; Chan, Raymond C. K; Reis Marques, Tiago; Collier, David A; Reichenberg, Avi; Murray, Robin M; Tansella, Michele; Ruggeri, Mirella; Dazzan, Paola

Title:

Association between the COMT gene and neurological abnormalities and poorer executive function in psychosis

Year:

2015

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

PSYCHIATRY RESEARCH

ISSN of journal:

0165-1781

N° Volume:

230

Number or Folder:

2

:

Elsevier Science Ireland Limited:PO Box 85, Limerick Ireland:011 353 61 709600, 011 353 61 61944, EMAIL: usinfo-f@elsevier.com, INTERNET: http://www.elsevier.com, Fax: 011 353 61 709114

Page numbers:

742-743

Keyword:

COMT, esecutive function, NSS, neurological abnormalities, schizophrenia, psychosis

Short description of contents:

Objective: Motor and sensory neurological dysfunctions, and executive dysfunction, present in excess in psychosis, could reflect the same pathophysiological process possibly involving the prefrontal cortex. The COMT Val158Met may influence these impairments by affecting the function of prefrontal regions. We tested in a large cohort of Caucasian patients with psychosis whether subjects homozygous for the Val158 allele had greater neurological impairments and worse executive performance. Method: We evaluated 211 individuals with psychosis from four different cohorts recruited in Italy and UK. All patients underwent neurological and neuropsychological evaluations, and were genotyped for the COMT Val158Met (rs4680) polymorphism. Results: Patients with higher motor sequencing scores exhibited a worse block design performance (ANCOVA, p=0.002). Individuals with high motor sequencing signs and poorer executive function were significantly more likely to be homozygotes for the Met158 allele (Chi Square, p=0.016). Conclusion: Our finding of an association between the Met158 allele and both neurological and executive deficits was not predicted and needs to be replicated.

Web page:

https://doi.org/10.1016/j.psychres.2015.05.105

Product ID:

89797

Handle IRIS:

11562/932032

Last Modified:

November 15, 2022

Bibliographic citation:

Tosato, Sarah; Ira, Elisa; Russo, Manuela; Iyegbe, Conrad; Lasalvia, Antonio; Di Forti, Marta; Morgan, Kevin; Bonetto, Chiara; Morgan, Craig; De Rossi, Moreno; Nicolau, Stylianos; Chan, Raymond C. K; Reis Marques, Tiago; Collier, David A; Reichenberg, Avi; Murray, Robin M; Tansella, Michele; Ruggeri, Mirella; Dazzan, Paola, Association between the COMT gene and neurological abnormalities and poorer executive function in psychosis «PSYCHIATRY RESEARCH» , vol. 230 , n. 2 , 2015 , pp. 742-743

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo