Pubblicazioni

Autori:

Magrinelli, Francesca; Picelli, Alessandro; Tocco, Pierluigi; Federico, Angela; Roncari, Laura; Smania, Nicola; Zanette, Giampietro; Tamburin, Stefano

Titolo:

Pathophysiology of motor dysfunction in Parkinson’s Disease as the rationale for drug treatment and rehabilitation

Anno:

2016

Tipologia prodotto:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Lingua:

Inglese

Formato:

Elettronico

Referee:

Sì

Nome rivista:

PARKINSON'S DISEASE

ISSN Rivista:

2090-8083

N° Volume:

2016

Intervallo pagine:

1-18

Parole chiave:

Parkinson’s disease; pathophysiology; motor dysfunction; treatment; rehabilitation; review

Breve descrizione dei contenuti:

Cardinal motor features of Parkinson’s disease (PD) include bradykinesia, rest tremor, and rigidity, which appear in the early stages of the disease and largely depend on dopaminergic nigrostriatal denervation. Intermediate and advanced PD stages are characterized by motor fluctuations and dyskinesia, which depend on complex mechanisms secondary to severe nigrostriatal loss and to the problems related to oral levodopa absorption, and motor and nonmotor symptoms and signs that are secondary to marked dopaminergic loss and multisystem neurodegeneration with damage to nondopaminergic pathways. Nondopaminergic dysfunction results in motor problems, including posture, balance and gait disturbances, and fatigue, and nonmotor problems, encompassing depression, apathy, cognitive impairment, sleep disturbances, pain, and autonomic dysfunction. There are a number of symptomatic drugs for PD motor signs, but the pharmacological resources for nonmotor signs and symptoms are limited, and rehabilitation may contribute to their treatment. The present review will focus on classical notions and recent insights into the neuropathology, neuropharmacology, and neurophysiology of motor dysfunction of PD. These pieces of information represent the basis for the pharmacological, neurosurgical, and rehabilitative approaches to PD.

Pagina Web:

http://dx.doi.org/10.1155/2016/9832839

Id prodotto:

92387

Handle IRIS:

11562/945452

ultima modifica:

30 novembre 2022

Citazione bibliografica:

Magrinelli, Francesca; Picelli, Alessandro; Tocco, Pierluigi; Federico, Angela; Roncari, Laura; Smania, Nicola; Zanette, Giampietro; Tamburin, Stefano, Pathophysiology of motor dysfunction in Parkinson’s Disease as the rationale for drug treatment and rehabilitation «PARKINSON'S DISEASE» , vol. 2016 , 2016 , pp. 1-18

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