Publications

Authors:

Aureli, Massimo; Schiumarini, Domitilla; Loberto, Nicoletta; Bassi, Rosaria; Tamanini, Anna; Mancini, Giulia; Tironi, Matteo; Munari, Silvia; Cabrini, Giulio; Dechecchi, Mariacristina; Sonnino, Sandro

Title:

Unravelling the role of sphingolipids in cystic fibrosis lung disease

Year:

2016

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Referee:

Sì

Name of journal:

Chemistry and Physics of Lipids

ISSN of journal:

0009-3084

N° Volume:

200

:

Elsevier Science Ireland Ltd.

Page numbers:

94-103

Keyword:

Cystic fibrosis; Inflammation; Lipid rafts; Sphingolipids

Short description of contents:

Cystic fibrosis (CF), one of the most common lethal hereditary diseases of white European populations, is caused by loss-of-function mutations in the CF Transmembrane conductance Regulator (CFTR) gene. One of the main causes of mortality is the onset of CF lung disease, which is characterized by chronic infection and inflammation resulting in the progressive remodelling, irreversible damage and fibrosis of the airways. An increasing number of studies indicate that sphingolipids are crucial players in pulmonary manifestations of CF, even if their direct involvement in CF lung disease is still unclear. In this review, we give an overview of the role of sphingolipids in CF pulmonary disease, focusing on the relationship between glycosphingolipids and lung inflammation, which represents the main hallmark of this disease.

Product ID:

95541

Handle IRIS:

11562/957342

Last Modified:

November 15, 2022

Bibliographic citation:

Aureli, Massimo; Schiumarini, Domitilla; Loberto, Nicoletta; Bassi, Rosaria; Tamanini, Anna; Mancini, Giulia; Tironi, Matteo; Munari, Silvia; Cabrini, Giulio; Dechecchi, Mariacristina; Sonnino, Sandro, Unravelling the role of sphingolipids in cystic fibrosis lung disease «Chemistry and Physics of Lipids» , vol. 200 , 2016 , pp. 94-103

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo