Publications

Authors:

Gajofatto, Alberto; Turatti, Marco; Benedetti, Mariadonata

Title:

Primary progressive multiple sclerosis: current therapeutic strategies and future perspectives

Year:

2017

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

EXPERT REVIEW OF NEUROTHERAPEUTICS

ISSN of journal:

1473-7175

N° Volume:

17

Number or Folder:

4

Page numbers:

393-406

Keyword:

disease-modifying therapy; immunomodulatory drugs; immunosuppressive drugs; multiple sclerosis; ocrelizumab; primary progressive; treatment

Short description of contents:

Multiple sclerosis (MS) is a chronic inflammatory condition of the central nervous system with heterogeneous features. Primary progressive (PP) MS is a rare disease subtype characterized by continuous disability worsening from onset. No disease-modifying therapy is currently approved for PP MS due to the negative or inconsistent results of clinical trials conducted on a wide range of interventions, which are reviewed in the present paper. Areas covered: The features and results of randomized trials of disease-modifying treatments for PP MS are discussed, including immunosuppressants, immunomodulators, monoclonal antibodies, and putative neuroprotective agents. Expert Commentary: The recent encouraging results of the ocrelizumab trial in PP MS, the first to reach the primary disability endpoint, indicate B cells as a promising therapeutic target to prevent disease progression. Other emerging treatment strategies include cell metabolism modulation and inflammatory pathways inhibition, which are being investigated in several ongoing phase II and III placebo-controlled trials. Future PP MS trials will need to systematically include efficacy endpoints other than physical disability alone, such as cognition, quality of life, advanced MRI measures and molecular biomarkers.

Web page:

http://dx.doi.org/10.1080/14737175.2017.1257385

Product ID:

96372

Handle IRIS:

11562/959202

Last Modified:

November 15, 2022

Bibliographic citation:

Gajofatto, Alberto; Turatti, Marco; Benedetti, Mariadonata, Primary progressive multiple sclerosis: current therapeutic strategies and future perspectives «EXPERT REVIEW OF NEUROTHERAPEUTICS» , vol. 17 , n. 4 , 2017 , pp. 393-406

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