Publications

Authors:

Pedrinolla, Anna; Schena, Federico; Venturelli, Massimo

Title:

Resilience to Alzheimer's disease: the role of physical activity

Year:

2017

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

CURRENT ALZHEIMER RESEARCH

ISSN of journal:

1567-2050

N° Volume:

14

Number or Folder:

5

Page numbers:

546-553

Keyword:

Alzheimer's disease; exercise; brain resilience; neuroendocrine resilience; cardiovascular resilience; mitochondrial resilience

Short description of contents:

BACKGROUND: Although Alzheimer's disease (AD) is a neurodegenerative pathology characterized by accumulation of β-amyloid plaques and neurofibrillary tangles at cerebral level, recent studies highlighted that AD might be the result of many altered physiological processes occurring at whole-organism level. The ability to adapt to stressors by "bending" but not "breaking" can be considered as "resilience". Individuals incline to withstand such pathophysiological challenges, can be considered more resilient than those that do not. Noticeably, recent literature provide evidence of several exercise-induced positive effects in AD patients including improved brain plasticity, increased adrenal sensitivity, increased vascular health, ameliorations of nitric oxide bioavailability and mitochondrial function. This review explores what resilience means in the AD milieu and the physiological mechanisms by which physical activity may mediate adaptive positive processes that enhance resilience. METHODS: A comprehensive PubMed search was conducted to identify studies about the role of exercise in AD resiliency. The following terminology was applied: Alzheimer resilience, brain resilience, metabolic resilience, cardiovascular resilience, mitochondrial resilience and exercise resilience. RESULTS: Seventy-three studies were included. Five papers defined Alzheimer's resilience, 15 papers brain resilience, five cardiovascular resilience, one metabolic resilience, 11 mitochondrial resilience, and 7 exercise resilience. Other twenty-six paper were identified from reference list of authors' knowledge. CONCLUSION: knowing that disturbances in brain, neuroendocrine, vascular and mitochondria metabolism are important events in neurodegeneration and dementia development, the ability of exercise to trigger adaptive mechanisms might represent an important non-pharmacological strategy to improve resilience to AD.

Web page:

https://doi.org/10.2174/1567205014666170111145817
http://www.eurekaselect.com/149167/article#

Product ID:

96881

Handle IRIS:

11562/960400

Last Modified:

November 15, 2022

Bibliographic citation:

Pedrinolla, Anna; Schena, Federico; Venturelli, Massimo, Resilience to Alzheimer's disease: the role of physical activity «CURRENT ALZHEIMER RESEARCH» , vol. 14 , n. 5 , 2017 , pp. 546-553

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo