Publications

Authors:

Bo, Marco; Niegowska, Magdalena; Arru, Giannina; Sechi, Elia; Mariotto, Sara; Mancinelli, Chiara; Farinazzo, Alessia; Alberti, Daniela; Gajofatto, Alberto; Ferrari, Sergio; Capra, Ruggero; Monaco, Salvatore; Sechi, Gianpietro; Sechi, Leonardo A

Title:

Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder

Year:

2018

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

Journal of Neuroimmunology

ISSN of journal:

0165-5728

N° Volume:

318

Page numbers:

97-102

Keyword:

AQP4; Epstein-Barr virus; IRF5; MBP; Mycobacterium avium subsp. paratuberculosis; neuromyelitis optica spectrum disorder

Short description of contents:

Epstein-Barr virus (EBV) is the main environmental agent associated to neuromyelitis optica spectrum disorder (NMOSD). Following to studies reporting an increased prevalence of antibodies against peptides derived from Mycobacterium avium subsp. paratuberculosis (MAP) homologous to EBV and human epitopes (MBP85-98, IRF5424-434) in multiple sclerosis (MS), we investigated whether seroreactivity to these antigens display a NMOSD-specific pattern. The sera of 34 NMOSD patients showed elevated levels of antibodies against MAP and MBP compared to healthy controls (44% vs. 5%, p < 0.0002 and 50% vs. 2%, p < 0.0001, respectively), while, unlike in MS, responsiveness to EBV was similar.

Web page:

https://doi.org/10.1016/j.jneuroim.2018.02.013

Product ID:

101650

Handle IRIS:

11562/976191

Last Modified:

April 1, 2023

Bibliographic citation:

Bo, Marco; Niegowska, Magdalena; Arru, Giannina; Sechi, Elia; Mariotto, Sara; Mancinelli, Chiara; Farinazzo, Alessia; Alberti, Daniela; Gajofatto, Alberto; Ferrari, Sergio; Capra, Ruggero; Monaco, Salvatore; Sechi, Gianpietro; Sechi, Leonardo A, Mycobacterium avium subspecies paratuberculosis and myelin basic protein specific epitopes are highly recognized by sera from patients with Neuromyelitis optica spectrum disorder «Journal of Neuroimmunology» , vol. 318 , 2018 , pp. 97-102

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo