HCV RNA genomic sequences and HCV-E2 glycoprotein in sural nerve biopsies from hcv-infected patients with peripheral neuropathy
Year:
2018
Type of item:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Language:
Inglese
Format:
A Stampa
Referee:
Sì
Name of journal:
Neuropathology and Applied Neurobiology
ISSN of journal:
0305-1846
N° Volume:
44
Number or Folder:
4
Page numbers:
427-438
Keyword:
E2-glycoprotein; hepatitis C virus; mixed cryoglobulinemia; peripheral neuropathy
Short description of contents:
Peripheral neuropathy (PN), the major neurological complication of chronic HCV infection, is frequently associated with mixed cryoglobulinemia (MC) and small-vessel systemic vasculitis. While humoral and cell-mediated immune mechanisms are suspected to act together in an aberrant immune response that results in peripheral nerve damage, the role of HCV remains largely speculative. The possible demonstration of HCV in peripheral nerve tissue would obviously assume important pathogenic implications.