HCV RNA genomic sequences and HCV-E2 glycoprotein in sural nerve biopsies from hcv-infected patients with peripheral neuropathy
Anno:
2018
Tipologia prodotto:
Articolo in Rivista
Tipologia ANVUR:
Articolo su rivista
Lingua:
Inglese
Formato:
A Stampa
Referee:
Sì
Nome rivista:
Neuropathology and Applied Neurobiology
ISSN Rivista:
0305-1846
N° Volume:
44
Numero o Fascicolo:
4
Intervallo pagine:
427-438
Parole chiave:
E2-glycoprotein; hepatitis C virus; mixed cryoglobulinemia; peripheral neuropathy
Breve descrizione dei contenuti:
Peripheral neuropathy (PN), the major neurological complication of chronic HCV infection, is frequently associated with mixed cryoglobulinemia (MC) and small-vessel systemic vasculitis. While humoral and cell-mediated immune mechanisms are suspected to act together in an aberrant immune response that results in peripheral nerve damage, the role of HCV remains largely speculative. The possible demonstration of HCV in peripheral nerve tissue would obviously assume important pathogenic implications.