Publications

Authors:

Arru, Giannina; Mameli, Giuseppe; Deiana, Giovanni Andrea; Rassu, Anna Laura; Piredda, Rosanna; Sechi, Elia; Caggiu, Elisa; Bo, Marco; Nako, Enri; Urso, Daniele; Mariotto, Sara; Ferrari, Sergio; Zanusso, Gianluigi; Monaco, Salvatore; Sechi, Gianpietro; Sechi, Leonardo A

Title:

Humoral immunity response to HERV-K/W differentiates between amyotrophic lateral sclerosis and other neurological diseases

Year:

2018

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

A Stampa

Referee:

Sì

Name of journal:

European Journal Of Neurology

ISSN of journal:

1351-5101

N° Volume:

25

Number or Folder:

8

Page numbers:

1076-e84

Keyword:

Alzheimer disease; HERV-K; HERV-W; amyotrophic lateral sclerosis; humoral immunity; multiple sclerosis

Short description of contents:

BACKGROUND AND PURPOSE: Human endogenous retroviruses-K/W seem play a role in fostering and exacerbation of some neurological diseases, including amyotrophic lateral sclerosis (ALS). Given these findings, we investigated the immunity response against HERV-K and HERV-W envelope surface (env-su) glycoprotein antigens in serum and cerebrospinal fluid (CSF) of ALS, multiple sclerosis (MS) and Alzheimer's disease (AD) patients, and in healthy controls (HCs). METHODS: Four antigenic peptides derived respectively from HERV-K and HERV-W env surface proteins were studied in twenty-one definite or probable ALS, twenty-six possible or definite relapsing-remitting (RR) MS, eighteen patients with AD and thirty-nine HCs. An indirect ELISA was set up to detect specific antibodies (Abs) against env surface peptides. RESULTS: Among the measured levels of Abs against the four different HERV-K peptide fragments, HERV-K env-su 19-37 only was significantly elevated in ALS compared to other groups, both in serum and CSF. Instead, among the Abs levels directed against the four different HERV-W peptide fragments, only HERV-W env-su 93-108 and HERV-W env-su 248-262 were significantly elevated, in serum and CSF of MS, compared to other groups. In ALS patients, the HERV-K env-su 19-37 antibodies levels were significantly correlated with clinical measures of disease severity, both in serum and CSF. CONCLUSIONS: Increased circulating levels of Abs directed against the HERV-W env-su 93-108 and HERV-W env-su 248-262 peptide fragments could serve as possible biomarkers in patients with MS. Similarly, increased circulating levels of Abs directed against the HERV-K env-su19-37 peptide fragment could serve as possible early novel biomarker in patients with ALS. This article is protected by copyright. All rights reserved.

Web page:

https://doi.org/10.1111/ene.13648

Product ID:

103558

Handle IRIS:

11562/982976

Last Modified:

November 15, 2022

Bibliographic citation:

Arru, Giannina; Mameli, Giuseppe; Deiana, Giovanni Andrea; Rassu, Anna Laura; Piredda, Rosanna; Sechi, Elia; Caggiu, Elisa; Bo, Marco; Nako, Enri; Urso, Daniele; Mariotto, Sara; Ferrari, Sergio; Zanusso, Gianluigi; Monaco, Salvatore; Sechi, Gianpietro; Sechi, Leonardo A, Humoral immunity response to HERV-K/W differentiates between amyotrophic lateral sclerosis and other neurological diseases «European Journal Of Neurology» , vol. 25 , n. 8 , 2018 , pp. 1076-e84

Consulta la scheda completa presente nel repository istituzionale della Ricerca di Ateneo