Publications

Authors:

Fiorio, Mirta

Title:

Chapter 12: Modulation of the motor system by placebo and nocebo effects

Year:

2018

Type of item:

Contributo in volume (Capitolo o Saggio)

Tipologia ANVUR:

Contributo in volume (Capitolo o Saggio)

Language:

Inglese

Format:

A Stampa

Book Title:

Neurobiology of the Placebo Effect Part II

ISBN:

978-0-12-815416-8

Page numbers:

297-319

Keyword:

Basal ganglia; Expectation; Fatigue; Force; Motor performance; Nocebo effect; Parkinson's disease; Placebo effect; Readiness potential; Transcranial magnetic stimulation

Short description of contents:

There is strong behavioral evidence that placebo and nocebo effects can influence aspects of motor performance like speed, force, and resistance to fatigue in athletes and non-athletes alike. These behavioral studies were essential for extending experimental investigation of the placebo and nocebo effects from the pain to the motor domain and to reveal how verbal suggestions and experiential learning are involved in shaping modulatory systems and related behavioral responses. However, the neural underpinnings of these effects in the motor domain are still largely unknown. Studies in healthy subjects demonstrated that the placebo-induced enhancement of force is associated with increased activity in the corticospinal system and that the placebo-induced reduction of fatigue can be disclosed by recording the readiness potential, an electrophysiological sign of movement preparation. Further evidence derives from studies in patients with Parkinson's disease that have directly demonstrated that placebo-induced improvements in motor symptoms are related to changes in subcortical neural firing activity and dopamine release. Future investigations are needed to better clarify the complex neural architecture underpinning the placebo and nocebo effects in the motor domain.

Web page:

https://doi.org/10.1016/bs.irn.2018.07.012

Product ID:

104047

Handle IRIS:

11562/984467

Last Modified:

November 15, 2022

Bibliographic citation:

Fiorio, Mirta, Chapter 12: Modulation of the motor system by placebo and nocebo effects Neurobiology of the Placebo Effect Part II , 2018 , pp. 297-319

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