Publications

Authors:

Pedrinolla, Anna; Venturelli, Massimo; Kirmizi, Emine; Moschetta, Federica; Zardini, Monica; Rudi, Doriana; Bacchi, Elisabetta; Schena, Federico; Moghetti, Paolo; Lanza, Massimo

Title:

Role of exercise in vascular function and inflammatory profile in age-related obesity

Year:

2018

Type of item:

Articolo in Rivista

Tipologia ANVUR:

Articolo su rivista

Language:

Inglese

Format:

Elettronico

Referee:

Sì

Name of journal:

JOURNAL OF IMMUNOLOGY RESEARCH

ISSN of journal:

2314-8861

N° Volume:

2018

Number or Folder:

7134235

Page numbers:

1-9

Keyword:

vascular function, inflammatory profile, obesity, ageing, exercise.

Short description of contents:

In western countries, aging is often accompanied by obesity and age-related obesity is characterized by vascular dysfunction and a low-grade inflammatory profile. Exercise is a nonpharmacological strategy able to decrease the development and incidence of risk factors for several health-threatening diseases. Nonetheless, its long-term effect on vascular function and inflammation in age- related obesity is still unclear. The aim of this study was to investigate the effect of regular, supervised exercise on inflammatory profile and vascular function in age-related obesity. We also hypothesized that vascular function and inflammatory profile would have been correlated in overweight and obese individuals. Thirty normal weight (NW; 70 ± 5 years, 23.9 ± 2.6 BMI) and forty overweight and obese elderly (OW&OB; 69±5 years, 30.1±2.3 BMI) regularly taking part in a structured, supervised exercise program were enrolled in the study and evaluated for vascular function (flow-mediated dilation; FMD) and inflammatory profile (plasma CRP, IL-1β, IL-1ra, IL-6, IL-8, IL-10, TNF-α, and MCP-1). Although no differences between groups were found concerning performance and the weekly amount of physical activity, the OW&OB group compared with the NW group demonstrated higher systolic and diastolic blood pressure (+10%, p = 0 001; +9%, p = 0 005, respectively); lower FMD% (−36%, p < 0 001) and FMD/shear rate (−40%, p = 0 001); and higher levels of CRP (+33%, p = 0 005), IL-6 (+36%, p = 0 048), MCP-1 (+17%, p = 0 004), and TNF-α (+16%, p = 0 031). No correlations between vascular function and inflammation were found in OW&OB or NW. Although exercising regularly, overweight and obese elderly exhibited poorer vascular function and higher proinflammatory markers compared with the leaner group. These results support the idea that exercise alone cannot counteract the negative effect of adiposity on vascular function and inflammatory profile in elderly individuals and these two processes are not necessarily related.

Web page:

https://doi.org/10.1155/2018/7134235
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230399/

Product ID:

104699

Handle IRIS:

11562/986749

Last Modified:

November 15, 2022

Bibliographic citation:

Pedrinolla, Anna; Venturelli, Massimo; Kirmizi, Emine; Moschetta, Federica; Zardini, Monica; Rudi, Doriana; Bacchi, Elisabetta; Schena, Federico; Moghetti, Paolo; Lanza, Massimo, Role of exercise in vascular function and inflammatory profile in age-related obesity «JOURNAL OF IMMUNOLOGY RESEARCH» , vol. 2018 , n. 7134235 , 2018 , pp. 1-9

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